Mutations in the Leucine Repeat Rich Kinase-2 (LRRK2) gene have been reported in familial Parkinson's disease (PD) cases. We have generated induced pluripotent stem cells (iPSCs) using Sendai-virus reprogramming-method from peripheral blood mononuclear cells of PD-patient of East-Indian ethnicity carrying the I1371V mutation in LRRK2 gene. PD diagnosis was performed using Unified Parkinson's Disease rating scale (UPDRS) score and confirmed by [¹⁸F]fluoro-l-dopa [F-DOPA] positron emission tomography (F-DOPA PET). The iPSC line was characterized for self-renewal and pluripotency. This cellular model will provide a valuable resource not only for drug-screening platform but also to understand the pathophysiology of this disease.

在家族性帕金森氏病（PD）病例中已经报道了亮氨酸重复富集激酶2（LRRK2）基因突变。我们已经使用仙台病毒重编程法从东印度裔PD患者携带LRRK2基因中的I1371V突变的外周血单个核细胞中生成了诱导多能干细胞（iPSC）。使用统一帕金森氏病评分量表（UPDRS）评分进行PD诊断，并通过[ ¹⁸ F]氟-1-多巴[F-DOPA]正电子发射断层扫描（F-DOPA PET）进行确认。iPSC系列具有自我更新和多能性的特点。这种细胞模型不仅为药物筛选平台提供了宝贵的资源，而且为了解这种疾病的病理生理学提供了宝贵的资源。