Abstract Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane.

中文翻译：

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聚（乳酸 - 共 - 乙醇酸）与 β-磷酸三钙的电纺纤维膜用于引导骨再生应用

摘要 引导骨再生 (GBR) 已被证明在口腔种植学中治疗骨​​缺损方面取得了巨大成功。骨缺损通过使用屏障膜重建，该屏障膜可防止软组织侵入并为引导新骨生长进入骨缺损创造空间。为了开发具有更高生物活性的 GBR 膜，通过静电纺丝制造了含有 β-磷酸三钙（β-TCP）的聚（乳酸-乙醇酸共聚物）（PLGA）纤维膜。纤维中 5wt% 和 10wt% 的 β-TCP 的存在改善了机械性能。体外生物相容性结果表明，所有膜都是无细胞毒性的，β-TCP 的存在增加了细胞粘附和增殖。此外，细胞活力结果表明，5 wt% β-TCP 的存在有利于成骨细胞增殖。