During the 25 years since the US Congress passed the Dietary Supplement Health and Education Act (DSHEA), the law that transformed the US Food and Drug Administration's (FDA's) authority to regulate dietary supplements, the dietary supplement market has grown exponentially. Retail sales of herbal products, a subcategory of dietary supplements, have increased 83% from 2008 to 2018 ($4.8 to $8.8 billion USD). Although consumers often equate "natural" with "safe", it is well recognized by scientists that constituents in these natural products (NPs) can result in toxicity. Additionally, when NPs are co-consumed with pharmaceutical agents, the precipitant NP can alter drug disposition and drug delivery, thereby enhancing or reducing the therapeutic effect of the object drug(s). With the widespread use of NPs, these effects can be underappreciated. We present a summary of a symposium presented at the Annual Meeting of the Society of Toxicology 2019 (12 March 2019) that discussed potential toxicities of NPs alone and in combination with drugs.

中文翻译：

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“天然”不是“安全”的代名词：天然产物单独或与药物结合使用时的毒性。

自美国国会通过《膳食补充剂健康与教育法案》（DSHEA）（该法律改变了美国食品和药物管理局（FDA）的法规来管理膳食补充剂的权威）以来的25年中，膳食补充剂市场呈指数增长。草药产品（膳食补充剂的一个子类别）的零售额从2008年至2018年增长了83％（从4.8美元增至88亿美元）。尽管消费者通常将“天然”等同于“安全”，但科学家们已经充分认识到，这些天然产品（NP）中的成分会导致毒性。另外，当NP与药剂共同消耗时，沉淀剂NP可以改变药物的处置和药物的递送，从而增强或降低目标药物的治疗效果。随着NP的广泛使用，这些影响可能会被低估。我们提供了在2019年毒理学学会年会（2019年3月12日）上举办的研讨会的摘要，该研讨会讨论了NP单独或与药物联合使用可能引起的毒性。