Postoperative pain is an outcome of importance to potential living kidney donors (LKDs). We prospectively characterized the prevalence, severity, and patterns of acute or chronic postoperative pain in 193 LKDs at six transplant programs. Three pain measurements were obtained from donors on postoperative Day (POD) 1, 3, 7, 14, 21, 28, 35, 41, 49, and 56. The median pain rating total was highest on POD1 and declined from each assessment to the next until reaching a median pain‐free score of 0 on POD49. In generalized linear mixed‐model analysis, the mean pain score decreased at each pain assessment compared to the POD3 assessment. Pre‐donation history of mood disorder (adjusted ratio of means [95% confidence interval (CI)]: 1.40 [0.99, 1.98]), reporting “severe” on any POD1 pain descriptors (adjusted ratio of means [95% CI]: 1.47 [1.12, 1.93]) and open nephrectomy (adjusted ratio of means [95% CI]: 2.61 [1.03, 6.62]) were associated with higher pain scores across time. Of the 179 LKDs who completed the final pain assessment, 74 (41%) met criteria for chronic postsurgical pain (CPSP), that is, any donation‐related pain on POD56. Study findings have potential implications for LKD education, surgical consent, postdonation care, and outcome measurements.

中文翻译：

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供体肾切除术后的疼痛预期、患病率、严重程度和模式：来自 KDOC 研究的结果。

术后疼痛对于潜在的活体肾脏捐献者 (LKD) 来说是一个重要的结果。我们前瞻性地描述了六个移植项目中 193 个 LKD 患者急性或慢性术后疼痛的患病率、严重程度和模式。在术后第 1、3、7、14、21、28、35、41、49 和 56 天从捐献者那里获得了三个疼痛测量值。中位疼痛评分总数在 POD1 最高，并且从每次评估到接下来，直到在 POD49 上达到中位无痛评分 0。在广义线性混合模型分析中，与 POD3 评估相比，每次疼痛评估的平均疼痛评分均有所降低。情绪障碍的捐献前史（调整后的均值比 [95% 置信区间 (CI)]：1.40 [0.99, 1.98]），在任何 POD1 疼痛描述符上报告“严重”（调整后的均值比 [95% CI]： 1.47 [1.12, 1. 93]）和开放性肾切除术（调整后的均值比 [95% CI]：2.61 [1.03, 6.62]）与较高的疼痛评分相关。在完成最终疼痛评估的 179 名 LKD 中，74 名 (41%) 符合慢性术后疼痛 (CPSP) 标准，即 POD56 上的任何捐献相关疼痛。研究结果对 LKD 教育、手术同意、捐赠后护理和结果测量具有潜在影响。