Non‐Hodgkin lymphoma (NHL) is the sixth most common cancer in Sub‐Saharan Africa (SSA). Comprehensive diagnostics of NHL are essential for effective treatment. Our objective was to assess the frequency of NHL subtypes, disease stage and further diagnostic aspects. Eleven population‐based cancer registries in 10 countries participated in our observational study. A random sample of 516 patients was included. Histological confirmation of NHL was available for 76.2% and cytological confirmation for another 17.3%. NHL subclassification was determined in 42.1%. Of these, diffuse large B cell lymphoma, chronic lymphocytic leukaemia and Burkitt lymphoma were the most common subtypes identified (48.8%, 18.4% and 6.0%, respectively). We traced 293 patients, for whom recorded data were amended using clinical records. For these, information on stage, human immunodeficiency virus (HIV) status and Eastern Cooperative Oncology Group Performance Status (ECOG PS) was available for 60.8%, 52.6% and 45.1%, respectively. Stage at diagnosis was advanced for 130 of 178 (73.0%) patients, HIV status was positive for 97 of 154 (63.0%) and ECOG PS was ≥2 for 81 of 132 (61.4%). Knowledge about NHL subclassification and baseline clinical characteristics is crucial for guideline‐recommended treatment. Hence, regionally adapted investments in pathological capacity, as well as standardised clinical diagnostics, will significantly improve the therapeutic precision for NHL in SSA.

中文翻译：

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撒哈拉以南非洲成年非霍奇金淋巴瘤患者的临床表现和诊断。

非霍奇金淋巴瘤（NHL）是撒哈拉以南非洲（SSA）第六大最常见的癌症。NHL的全面诊断对于有效治疗至关重要。我们的目标是评估NHL亚型的频率，疾病阶段和进一步的诊断方面。在10个国家/地区的11个基于人口的癌症登记处参加了我们的观察性研究。随机抽取516名患者。NHL的组织学确认率为76.2％，细胞学确认率为17.3％。NHL的子分类确定为42.1％。其中，弥散性大B细胞淋巴瘤，慢性淋巴细胞性白血病和Burkitt淋巴瘤是最常见的亚型（分别为48.8％，18.4％和6.0％）。我们追踪了293例患者，使用临床记录对其记录数据进行了修改。对于这些，舞台上的信息，人类免疫缺陷病毒（HIV）状态和东部合作肿瘤小组表现状态（ECOG PS）分别为60.8％，52.6％和45.1％。178名患者中的130名（73.0％）进入诊断阶段，154名中97名（63.0％）的HIV阳性，132名中81名（61.4％）的ECOG PS≥2。有关NHL亚分类和基线临床特征的知识对于指南推荐的治疗至关重要。因此，在病理能力以及标准化临床诊断方面进行区域适应性投资，将显着提高SSA中NHL的治疗精度。HIV阳性为154例中的97例（63.0％），ECOG PS≥132中的81例为2（61.4％）。有关NHL亚分类和基线临床特征的知识对于指南推荐的治疗至关重要。因此，在病理能力上进行区域适应性投资以及标准化的临床诊断将显着提高SSA中NHL的治疗精度。HIV阳性为154例中的97例（63.0％），ECOG PS≥132中的81例为2（61.4％）。有关NHL亚分类和基线临床特征的知识对于指南推荐的治疗至关重要。因此，在病理能力上进行区域适应性投资以及标准化的临床诊断将显着提高SSA中NHL的治疗精度。