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Nanoerythrocyte Membrane–Enveloped ROS‐Responsive 5‐Aminolevulinic Acid Prodrug Nanostructures with Robust Atheroprotection
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2020-03-17 , DOI: 10.1002/ppsc.202000021
Ali Maruf 1 , Yi Wang 1 , Li Luo 1 , Yuan Zhong 1, 2 , Deti Nurhidayah 1 , Boyan Liu 1 , Dan Tang 1 , Muhammad Abdul Rouf 1 , Haijun Zhang 3 , Yuxia Yin 4 , Wei Wu 1 , Guixue Wang 1
Affiliation  

The development of smart nanoagents that can respond to a specific stimulus has gained remarkable interest for treating various kinds of diseases, including atherosclerosis. On the other hand, a cell camouflaging strategy has been considered as a pivotal factor to improve the delivery stealthiness, biocompatibility, and biodegradability of nanocarriers, resolving the shortcomings of PEGylation. In this study, reactive oxygen species (ROS)‐responsive 5‐aminolevulinic acid (ALA) prodrug nanostructures (ROSELLA) encapsulating rapamycin (RAP) are blended with nanoerythrocyte membranes to construct red blood cell membrane (RBCM)/RAP@ROSELLA. These nanoagents are designed to be able to escape the biological barriers, accumulate in atherosclerosis lesions, and enhance the release of drugs in the intracellular milieu due to the magnification of hydrogen peroxide (H2O2). In vitro study proves its superior ability to inhibit the proliferation of macrophages and vascular smooth muscle cells. In vivo developmental toxicity further confirms that no significant systematic toxicity is induced by RBCM/RAP@ROSELLA, implying its favorable biocompatibility, which has potential for precise nanomedicine to combat atherosclerosis.

中文翻译:

纳米红细胞膜包裹的具有ROSS响应的5-氨基乙酰丙酸前药纳米结构,具有强大的动脉粥样硬化保护能力

可以响应特定刺激的智能纳米药物的开发已引起人们对治疗包括动脉粥样硬化在内的各种疾病的浓厚兴趣。另一方面,细胞伪装策略已被认为是改善纳米载体的传递隐身性,生物相容性和生物降解性的关键因素,从而解决了聚乙二醇化的缺点。在这项研究中,将包裹雷帕霉素(RAP)的活性氧(ROS)响应型5-氨基乙酰丙酸(ALA)前药纳米结构(ROSELLA)与纳米红细胞膜混合,以构建红细胞膜(RBCM)/ RAP @ ROSELLA。这些纳米剂旨在逃避生物屏障,积聚在动脉粥样硬化病变中,2 O 2)。体外研究证明其抑制巨噬细胞和血管平滑肌细胞增殖的优异能力。体内发育毒性进一步证实,RBCM / RAP @ ROSELLA不会诱导明显的系统毒性,这表明其良好的生物相容性,这对于精确的纳米药物具有抗动脉粥样硬化的潜力。
更新日期:2020-03-17
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