Detachable microneedle (MN) technology is highly desired for treatment of ocular diseases such as keratitis or glaucoma because of its minimally invasiveness and sustained drug delivery. However, shortening of administration time during insertion into target tissues still remains an important issue, although various approaches using mechanical and chemical separation mechanisms have been attempted. Here, a rapidly detachable microneedle pen (RD‐MNP) containing a porous dissolvable sacrificial layer is fabricated for instant separation of the tip. The porous sacrificial layer is fabricated between a drug‐loaded tip and a base by freeze drying. The sacrificial layer is comprised of water soluble polymers: poly(vinyl alcohol) (PVA) and poly(vinyl pyrrolidone) (PVP). Porous structure can accelerate dissolution rate compared to solid structure due to its capillary effect that relies on pore size and distribution. The pore size and distribution of the sacrificial layer are controlled and detachment of an RD‐MNP with the optimum pore structures is immediate upon dipping the MNP in PBS. Furthermore, the insertion characteristics of the system are investigated using the gelatin phantom and porcine eye sclera. With the optimized sacrificial layer, a MN tip is almost immediately detached and embedded to the porcine sclera with the aid of impact insertion.

中文翻译：

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使用多孔水溶性层可快速拆卸的微针眼药

由于可拆式微针（MN）技术具有最小的侵入性和持续的药物输送性，因此非常需要用于治疗眼病（例如角膜炎或青光眼）。然而，尽管已经尝试了使用机械和化学分离机制的各种方法，但是缩短插入目标组织期间的给药时间仍然是重要的问题。在这里，制造了一种可快速拆卸的微针笔（RD-MNP），其中包含一个多孔的可溶牺牲层，可即时分离笔尖。多孔牺牲层是通过冷冻干燥在载药的针尖和基底之间制成的。牺牲层由水溶性聚合物组成：聚乙烯醇（PVA）和聚乙烯吡咯烷酮（PVP）。与固体结构相比，多孔结构由于其毛细作用取决于孔径和分布，因此可以加快溶解速度。牺牲层的孔径和分布受到控制，将MNP浸入PBS中后，具有最佳孔结构的RD-MNP就会立即脱离。此外，使用明胶体模和猪眼巩膜研究了系统的插入特性。通过优化的牺牲层，借助撞击插入，MN尖端几乎立即脱离并嵌入到猪巩膜中。使用明胶体模和猪眼巩膜研究了系统的插入特性。通过优化的牺牲层，借助撞击插入，MN尖端几乎立即脱离并嵌入到猪巩膜中。使用明胶体模和猪眼巩膜研究了系统的插入特性。通过优化的牺牲层，借助撞击插入，MN尖端几乎立即脱离并嵌入到猪巩膜中。