A novel ratiometric fluorescent probe for the detection of hydrogen peroxide in human gastric carcinoma HGC-27 cells,Analytical Methods

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A novel ratiometric fluorescent probe for the detection of hydrogen peroxide in human gastric carcinoma HGC-27 cells
Analytical Methods ( IF 3.1 ) Pub Date : 2020/03/17 , DOI: 10.1039/c9ay02263e
Yong Xie _{1,

2,

3,

4,

5} , Zhu Chen _{2,

3,

4,

5,

6} , Linan Hu _{2,

3,

4,

5,

6} , Hailiang Zhang _{5,

7,

8,

9,

10} , Pengfei Xu _{5,

7,

8,

9,

10} , Ke Pan _{1,

2,

3,

4,

5}

Affiliation

Hydrogen peroxide (H₂O₂) has been recognized as one of the most significant ROS in human health and disease. In this work, we report a new fluorescent probe JNH-1 for the ratiometric detection of H₂O₂. The probe JNH-1 showed a highly selective fluorescent response to H₂O₂ against other interferences of ROS and RNS. In addition, this probe was successfully applied for the monitoring and imaging of H₂O₂ in living human gastric carcinoma HGC-27 cells.

中文翻译：

用于检测人胃癌HGC-27细胞中过氧化氢的新型比例荧光探针

过氧化氢（H ₂ O ₂）被公认为是人类健康和疾病中最重要的ROS之一。在这项工作中，我们报告了一种用于H ₂ O ₂比例检测的新型荧光探针JNH-1。探针JNH-1对H ₂ O _2表现出对ROS和RNS的其他干扰的高度选择性荧光响应。此外，该探针已成功地用于活人胃癌HGC-27细胞中H ₂ O ₂的监测和成像。

更新日期：2020-03-27

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