Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. Here, we discuss the role of mitochondria in maintaining cellular and whole-organism homeostasis, the mechanisms that promote mitochondrial dysfunction and the role of this phenomenon in noncommunicable chronic diseases. We also review the state of the art regarding the pre-clinical evidence associated with the regulation of the mitochondrial function and the development of current mitochondrial-targeted therapeutics to treat non communicable chronic diseases. Finally; we give an integrated vision of how the mitochondrial damage is implicated in these metabolic diseases.

中文翻译：

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线粒体功能障碍是非传染性慢性疾病的常见根源吗？

线粒体损伤被认为是许多非传染性慢性疾病的主要贡献因素，例如心血管疾病，癌症，肥胖症和胰岛素抵抗/ 2型糖尿病。在这里，我们讨论了线粒体在维持细胞和整个生物体内稳态中的作用，促进线粒体功能障碍的机制以及这种现象在非传染性慢性疾病中的作用。我们还回顾了有关与线粒体功能调节相关的临床前证据以及当前针对治疗非传染性慢性疾病的线粒体靶向疗法的发展情况。最后; 我们给出了线粒体损伤如何与这些代谢疾病有关的综合见解。