While the effects of an antenatal dietary intervention for women with obesity or overweight on pregnancy and newborn health have been extensively studied, the longer-term effects into childhood are unknown. We followed children born to women who participated in the LIMIT randomised trial, where pregnant women were randomised to an antenatal dietary and lifestyle intervention or standard antenatal care. Our aim was to assess the effect of the intervention, on child outcomes at 3–5 years of age on children whose mothers provided consent. We assessed 1418 (Lifestyle Advice n = 727; Standard Care n = 691) (66.9%) of the 2121 eligible children. There were no statistically significant differences in the incidence of child BMI z-score >85th centile for children born to women in the Lifestyle Advice Group, compared with the Standard Care group (Lifestyle Advice 444 (41.73%) versus Standard Care 417 (39.51%); adjusted relative risk (aRR) 1.05; 95% confidence intervals 0.93–1.19; p = 0.42). There were no significant effects on measures of child growth, adiposity, neurodevelopment, or dietary intake. There is no evidence that an antenatal dietary intervention altered child growth and adiposity at age 3–5 years. This cohort of children remains at high risk of obesity, and warrants ongoing follow-up.

虽然已经广泛研究了产前饮食干预对肥胖或超重妇女对怀孕和新生儿健康的影响，但对儿童期的长期影响尚不清楚。我们追踪了参与 LIMIT 随机试验的妇女所生的孩子，在该试验中，孕妇被随机分配接受产前饮食和生活方式干预或标准产前护理。我们的目的是评估干预对 3-5 岁时母亲同意的儿童的结果的影响。我们评估 了 2121 名符合条件的儿童中的1418 名（生活方式建议n  = 727；标准护理n = 691）（66.9%）。儿童 BMI z的发生率无统计学差异- 与标准护理组相比，生活方式建议组中女性所生子女的得分 >85%（生活方式建议 444 (41.73%) 与标准护理 417 (39.51%)；调整后的相对风险 (aRR) 1.05；95% 置信度）间隔 0.93–1.19；p  = 0.42）。对儿童生长、肥胖、神经发育或饮食摄入量的测量没有显着影响。没有证据表明产前饮食干预会改变 3-5 岁儿童的生长和肥胖。这群儿童仍然处于肥胖的高风险中，需要进行持续的随访。