BACKGROUND Malnutrition is confirmed to be associated with poor outcomes in stroke patients. The present study aimed to confirm that being at risk of malnutrition assessed by Nutritional Risk Screening Tool 2002 (NRS-2002) and the Controlling Nutritional Status (CONUT) score predicts poor outcomes at 3 months in acute ischemic stroke (AIS) patients. METHODS In total, 682 patients with AIS were recruited within 7 days of stroke onset consecutively and 110 were dropped out. They were screened for risk of malnutrition using NRS-2002 and the CONUT score. The primary outcome is the follow-up modified Rankin Scale (mRS) score. Poor outcomes were defined as an (mRS) score ≥ 3 at 3 months post discharge. RESULTS There was a significant difference in the mRS score at 3 months between patients at risk of malnutrition compared to those not at risk assessed by NRS-2002(P < 0.001) and CONUT (P = 0.011). The logistic regression model showed that the risk of malnourishment (according to NRS-2002), low risk of malnourishment (according to CONUT), and the moderate-to-severe risk of malnourishment (according to CONUT) were associated with higher risk of poor outcomes at 3 months (P < 0.001, P = 0.033, and P = 0.007). The multivariate logistic regression model (adjusted for confounding factors) demonstrated that the risk of malnourishment, according to the NRS-2002, was associated with the increasing risk of poor outcomes at 3 months (odds ratio = 2.31; 95% CI: 1.24-4.30; P = 0.008). CONCLUSIONS The risk of malnutrition assessed by NRS-2002 and CONUT can predict poor outcomes at 3 months in AIS patients. NRS-2002 is superior to CONUT in predicting poor outcomes at 3 months.

中文翻译：

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患有营养不良的风险预示着急性缺血性中风患者在3个月时的预后不良。

背景技术营养不良被证实与中风患者的不良预后有关。本研究旨在确认通过营养风险筛查工具2002（NRS-2002）和控制营养状况（CONUT）评分评估的处于营养不良风险中可预测急性缺血性卒中（AIS）患者在3个月时的不良结局。方法总共有682例AIS患者在卒中发作后7天内连续被招募，其中110例被退学。使用NRS-2002和CONUT评分筛查了他们的营养不良风险。主要结果是随访改良的Rankin量表（mRS）评分。不良结局定义为出院后3个月（mRS）评分≥3。结果营养不良风险患者与未接受NRS-2002评估的风险患者相比，营养不良风险患者在3个月时的mRS评分存在显着差异（P <0.001）和CONUT（P = 0.011）。Logistic回归模型显示，营养不良的风险（根据NRS-2002），营养不良的风险低（根据CONUT）和中度至重度的营养不良风险（根据CONUT）与贫困人口的较高风险相关3个月时的预后（P <0.001，P = 0.033，P = 0.007）。多元logistic回归模型（针对混杂因素进行了调整）表明，根据NRS-2002，营养不良的风险与3个月时不良结局的风险增加相关（赔率= 2.31； 95％CI：1.24-4.30） ； P = 0.008）。结论NRS-2002和CONUT评估的营养不良风险可以预测AIS患者3个月的预后不良。在预测3个月的不良结局方面，NRS-2002优于CONUT。