Background/Objectives

Fractional iron absorption (FAFe) from ferrous fumarate (FeFum) and ferrous sulfate (FeSO₄) in adults is generally comparable. While FeFum is commonly used to fortify infant foods, FAFe from FeFum in young children and infants may be decreased compared with FeSO₄ and this effect has not been assessed in inhibitory vs noninhibitory meals. Previous studies also reported FAFe to be strongly correlated in mother–child pairs. Our objective was to measure FAFe from fortified bread labeled with ⁵⁸FeSO₄ and ⁵⁷FeFum in mother–child pairs with and without a commonly consumed herbal tea of Combretum micranthum (Tisane Kinkéliba, TK).

Methods

Senegalese mother–child pairs (n = 17) were randomly assigned to receive, in a 2 × 2 factorial design, fortified bread with ⁵⁸FeSO₄ or ⁵⁷FeFum consumed with TK or water. FAFe was assessed by measuring erythrocyte incorporation of stable iron-isotopes 14 days after administration.

Results

In children, relative bioavailability (RBV) from FeFum was 51 and 64% compared with FeSO₄ when served with TK or water (both, P < 0.05). In mothers, the presence of TK decreased FAFe by 56% (P < 0.05) and 50% (P = 0.077) and in children by 65 and 72% (both, P < 0.0001), in the meals with ⁵⁸FeSO₄ and ⁵⁷FeFum, respectively. After adjustment for plasma ferritin, there was a positive correlation between FAFe in mothers and children (r = 0.4142, P = 0.001).

Conclusions

In Senegalese women and children, herbal tea decreased FAFe from a wheat-based meal. The RBV of FeFum was low in children but not in their mothers. FAFe was modestly correlated in mother–child pairs, possibly due to shared genetic, epigenetic or environmental background.

中文翻译：

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富含多酚的茶会降低塞内加尔母子对强化小麦面包中铁的吸收，并且富马酸亚铁的生物利用度在儿童中急剧降低。

背景/目标

成人中富马酸亚铁 (FeFum) 和硫酸亚铁 (FeSO ₄ ) 的铁吸收分数 (FAFe) 通常相当。_{虽然 FeFum 通常用于强化婴儿食品，但与 FeSO 4}相比，来自 FeFum 的幼儿和婴儿中的 FAFe 可能会降低，并且尚未在抑制性与非抑制性膳食中评估这种效果。先前的研究还报道了 FAFe 在母子对中具有很强的相关性。我们的目标是测量母子对中标有⁵⁸ FeSO ₄和⁵⁷ FeFum 的强化面包中的 FAFe，有和没有常见的小花草茶（Tisane Kinkéliba，TK）。

方法

塞内加尔母子对 ( n  = 17) 被随机分配接受 2 × 2 因子设计的强化面包，其中含有⁵⁸ FeSO ₄或⁵⁷ FeFum 与 TK 或水一起食用。通过在给药后 14 天测量红细胞中稳定铁同位素的掺入来评估 FAFe。

结果

_在儿童中，与 TK 或水一起服用时，FeFum 的相对生物利用度 (RBV) 分别为 51% 和 64% （两者均P  < 0.05）。^{在母亲中，在含有58} FeSO ₄和⁵⁷的膳食中，TK 的存在使 FAFe 降低了 56% ( P  < 0.05) 和 50% ( P  = 0.077)，儿童降低了 65% 和 72% (均P  < 0.0001) FeFum，分别。校正血浆铁蛋白后，母婴 FAFe 呈正相关（r  = 0.4142，P  = 0.001）。

结论

在塞内加尔妇女和儿童中，花草茶降低了小麦膳食中的 FAFe。FeFum 的 RBV 在儿童中较低，但在母亲中则不然。FAFe 在母子对中适度相关，可能是由于共同的遗传、表观遗传或环境背景。