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Unexpected Iodine-Promoted Aerobic Oxidation of α-Cyano-δ-keto Esters: A Facile Synthesis of α,δ-Dicarbonyl Esters
Synthesis ( IF 2.6 ) Pub Date : 2020-03-16 , DOI: 10.1055/s-0040-1707996
Ze Zhang 1 , Hui Xu , Ming-Yue Weng , Hong Chen
Affiliation  

An efficient and green method for the synthesis of various α,δ-dicarbonyl esters has been developed via a conjugate addition of ethyl cyanoacetates to chalcones and subsequent iodine-promoted aerobic oxidation. The present protocol features mild reaction conditions, high efficiency, easily available starting materials, and broad substrate scope.

中文翻译:

意外的碘促进α-氰基-δ-酮酯的好氧氧化:α,δ-二羰基酯的简便合成

通过将氰基乙酸乙酯共轭添加至查耳酮并随后进行碘促进的好氧氧化,已开发出一种高效且绿色的合成各种α,δ-二羰基酯的方法。本协议的特点是反应条件温和,高效,原料易得,底物范围广。
更新日期:2020-03-16
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