Hydroxyapatite-associated bacterial cellulose (BC/HA) is a promising composite for biomedical applications. However, this hybrid composite has some limitations due to its low in vivo degradability. The objective of this work was to oxidize BC and BC/HA composites for different time periods to produce 2,3 dialdehyde cellulose (DAC). The BC and oxidized BC (OxBC) membranes were mineralized to obtain the hybrid materials (BC/HA and OxBC/HA) and their physico-chemical, degradability, and bioactivity properties were studied. The results showed that OxBC/HA was more bioactive and degradable than BC/HA, which isa function of the degree of BC oxidation. High glucose levels in the BC degradation were observed as a function of oxidation degree, and other products, such as butyric acid and acetic acid resulted from DAC degradation. Therefore, this chemical modification reaction favors BC degradation, making it a good biodegradable and bioactive material with a potential for bone regeneration applications.

羟基磷灰石相关细菌纤维素（BC / HA）是一种有前途的生物医学应用复合材料。然而，这种杂合复合材料由于其体内活性低而具有一些局限性可降解性。这项工作的目的是在不同的时间段氧化BC和BC / HA复合材料，以生产2,3二醛纤维素（DAC）。将BC和氧化的BC（OxBC）膜矿化以获得杂化材料（BC / HA和OxBC / HA），并研究其物理化学，可降解性和生物活性。结果表明，OxBC / HA比BC / HA具有更高的生物活性和可降解性，这是BC氧化程度的函数。观察到BC降解中的高葡萄糖水平是氧化程度的函数，其他产物，例如DAC降解产生的丁酸和乙酸。因此，这种化学修饰反应有利于BC降解，使其成为具有良好生物可降解性和生物活性的材料，具有潜在的骨再生应用潜力。