当前位置: X-MOL 学术J. Inorg. Biochem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
DNA-binding of zinc(II) and nickel(II) salphen-like complexes extrapolated at 1 M salt concentration: Removing the ionic strength bias in physiological conditions.
Journal of Inorganic Biochemistry ( IF 3.9 ) Pub Date : 2020-03-17 , DOI: 10.1016/j.jinorgbio.2020.111064
Riccardo Bonsignore 1 , Gianluca Farine 2 , Claudio Migliore 2 , Giuseppe Gennaro 2 , Giampaolo Barone 2
Affiliation  

The DNA-binding of two salphen-like metal complexes of nickel(II) (1) and zinc(II) (2) was investigated in different ionic strength solutions by absorption spectroscopy. The data analysis allowed us to obtain the values of their extrapolated DNA-binding constant in physiological conditions, with DNA-binding strength in the order Ni > Zn, and to give relative weight to the electrostatic and non-electrostatic contributions to their DNA-interaction.

中文翻译:

在1 M盐浓度下推断的锌(II)和镍(II)连字符样复合物的DNA结合:消除生理条件下的离子强度偏差。

镍(II)(1)和锌(II)(2)的两种类似香肠的金属配合物在不同离子强度溶液中的吸收光谱研究。数据分析使我们能够在生理条件下获得其外推DNA结合常数的值,DNA结合强度的顺序为Ni> Zn,并给出相对于其DNA相互作用的静电和非静电作用的相对权重。
更新日期:2020-03-19
down
wechat
bug