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Network Centrality Reveals Dissociable Brain Activity during Response Inhibition in Human Right Ventral Part of Inferior Frontal Cortex.
Neuroscience ( IF 3.3 ) Pub Date : 2020-03-17 , DOI: 10.1016/j.neuroscience.2020.03.010
Uta Fujimoto 1 , Akitoshi Ogawa 1 , Takahiro Osada 1 , Masaki Tanaka 1 , Akimitsu Suda 2 , Nobutaka Hattori 3 , Koji Kamagata 4 , Shigeki Aoki 4 , Seiki Konishi 5
Affiliation  

The human right inferior frontal cortex (IFC) plays a critical role in response inhibition. It has also been demonstrated that the IFC is heterogeneous and that the ventral part of the IFC (vIFC) is more critical to inhibition of prepotent response tendency. Recent areal parcellation analyses based on resting-state functional connectivity have revealed that the right vIFC consists of multiple functional areas. In the present study, we characterized the parcellated areas (parcels) in the right vIFC using graph theory analysis, which characterizes local connectivity properties of a brain network by referring to its global structure of functional connectivity. Functional magnetic resonance imaging (MRI) scans were obtained during performance of a stop-signal task and during resting state. The cerebral cortex was parcellated into areas using resting-state functional connectivity. The parcels were then subjected to graph theory analysis to reveal central areas. Two parcels, ventral and dorsal, in the posterior part of the vIFC, exhibited significant brain activity during response inhibition. The ventral parcel exhibited a positive correlation between betweenness centrality and brain activity while the dorsal parcel did not. Correlations were significantly stronger in the ventral parcel. Moreover, the ventral parcel exhibited a negative correlation between brain activity during response inhibition and stop-signal reaction time (SSRT), a behavioral measure used to evaluate stopping performance. These dissociation results suggest that the ventral region in the vIFC plays a more central role in the brain network by increasing brain activity, which may further predict better performance of response inhibition.



中文翻译:

网络中枢揭示了在额叶下腹皮层右侧腹腔反应抑制过程中可分离的大脑活动。

右下额叶皮质(IFC)在抑制反应中起关键作用。还已经证明,IFC是异质的,并且IFC的腹侧部分(vIFC)对于抑制潜在的反应趋势更为关键。最近基于静止状态功能连接的区域分割分析显示,正确的vIFC包含多个功能区域。在本研究中,我们使用图论分析对右侧vIFC中的分隔区域(地块)进行了特征分析,该理论通过参考功能连接的全局结构来表征大脑网络的局部连接特性。在执行停止信号任务期间和在静止状态下均获得了功能磁共振成像(MRI)扫描。使用静止状态功能连接将大脑皮层分成多个区域。然后对包裹进行图论分析,以揭示中心区域。vIFC后部的两个腹侧和腹侧在反应抑制过程中均表现出明显的大脑活动。腹侧包裹性在中心性与大脑活动之间呈正相关,而背侧包裹性则没有。腹侧包裹的相关性明显更强。此外,腹侧包裹在反应抑制过程中的大脑活动与停止信号反应时间(SSRT)之间存在负相关关系,该信号是用来评估停止表现的行为指标。

更新日期:2020-03-19
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