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Relationship between rheological properties and transverse relaxation time (T2) of artificial and porcine vitreous humour.
Experimental Eye Research ( IF 3.4 ) Pub Date : 2020-03-17 , DOI: 10.1016/j.exer.2020.108006
Sachin S Thakur 1 , Xingzheng Pan 2 , Gamith L Kumarasinghe 3 , Naibo Yin 1 , Beau P Pontré 4 , Ehsan Vaghefi 2 , Ilva D Rupenthal 3
Affiliation  

Vitreous liquefactive processes play an integral role in ocular health. Knowledge of the degree of liquefaction would allow better monitoring of ocular disease progression and enable more informed therapeutic dosing for an individual patient. Presently this process cannot be monitored in a non-invasive manner. Here, we evaluated whether magnetic resonance imaging (MRI) could predict the viscoelasticity and in turn liquefactive state of artificial and biological vitreous humour. Gels comprising identical concentrations of hyaluronic acid and agar ranging from 0.125 to 2.25 mg/ml of each polymer were prepared and their T2 was measured using a turbo-spin echo sequence via 3T clinical MRI. The gels were subsequently subjected to rheological frequency and flow sweeps and trends between T2 and rheological parameters were assessed. The relationship between T2 and vitreous humour rheology was further assessed using ex vivo porcine eyes. An optimised imaging technique improved homogeneity of obtained artificial vitreous humour T2 maps. Strong correlations were observed between T2 and various rheological parameters of the gels. Translation to porcine vitreous humour demonstrated that the T2 of biological tissue was related to its viscoelastic properties. This study shows that T2 can be correlated with various rheological parameters within gels. Future investigations will assess the translatability of these findings to live models.

中文翻译:

人工和猪玻璃体液的流变特性与横向弛豫时间(T2)之间的关系。

玻璃液化过程在眼睛健康中起着不可或缺的作用。液化程度的知识将可以更好地监测眼部疾病的进展,并可以为单个患者提供更明智的治疗剂量。目前,该过程不能以非侵入性方式进行监视。在这里,我们评估了磁共振成像(MRI)是否可以预测粘弹性以及人造和生物玻璃体液的液化状态。制备包含相同浓度的透明质酸和琼脂的凝胶,每种聚合物的浓度范围为0.125至2.25 mg / ml,并使用涡轮旋转回波序列通过3T临床MRI测量其T2。随后使凝胶经受流变频率和流动扫描,并评估T 2和流变参数之间的趋势。使用离体猪眼进一步评估了T2和玻璃体流变学之间的关系。优化的成像技术改善了获得的人工玻璃体液T2图的同质性。在T2和凝胶的各种流变参数之间观察到强相关性。猪玻璃体液的翻译表明,生物组织的T2与其粘弹性有关。这项研究表明,T2可以与凝胶中的各种流变参数相关。未来的调查将评估这些发现与实时模型的可翻译性。在T2和凝胶的各种流变参数之间观察到强相关性。猪玻璃体液的翻译表明,生物组织的T2与其粘弹性有关。这项研究表明,T2可以与凝胶中的各种流变参数相关。未来的调查将评估这些发现与实时模型的可翻译性。在T2和凝胶的各种流变参数之间观察到强相关性。猪玻璃体液的翻译表明,生物组织的T2与其粘弹性有关。这项研究表明,T2可以与凝胶中的各种流变参数相关。未来的调查将评估这些发现与实时模型的可翻译性。
更新日期:2020-03-19
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