Chronic fatigue syndrome, postural orthostatic tachycardia syndrome, complex regional pain syndrome and silicone implant incompatibility syndrome are a subject of debate among clinicians and researchers. Both the pathogenesis and treatment of these disorders require further study. In this paper we summarize the evidence regarding the role of autoimmunity in these four syndromes with respect to immunogenetics, autoimmune co-morbidities, alteration in immune cell subsets, production of autoantibodies and presentation in animal models. These syndromes could be incorporated in a new concept of autoimmune neurosensory dysautonomia with the common denominators of autoantibodies against G-protein coupled receptors and small fiber neuropathy. Sjogren's syndrome, which is a classical autoimmune disease, could serve as a disease model, illustrating the concept. Development of this concept aims to identify an apparently autoimmune subgroup of the disputable disorders, addressed in the review, which may most benefit from the immunotherapy.

中文翻译：

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慢性疼痛，疲劳和认知障碍的综合症，与自身免疫性自主神经异常和小纤维神经病有关。

慢性疲劳综合症，体位性心动过速综合症，复杂的局部疼痛综合症和硅树脂植入物不相容综合症是临床医生和研究人员争论的话题。这些疾病的发病机理和治疗方法都需要进一步研究。在本文中，我们总结了关于免疫遗传学，自身免疫合并症，免疫细胞亚群改变，自身抗体产生和动物模型表现这四种综合症中自身免疫作用的证据。可以将这些综合征与自身免疫性神经感觉异常的新概念结合起来，这种疾病与针对G蛋白偶联受体和小纤维神经病的自身抗体的共同特征有关。干燥综合征是一种典型的自身免疫性疾病，可以作为疾病模型，说明概念。该概念的发展旨在鉴定本综述中讨论的明显有争议的疾病的自身免疫亚组，该亚组可能最受益于免疫疗法。