Development of new biocides has dominated human responses to evolution of antibiotic and pesticide resistance. Increasing and uniform biocide use, the spread of resistance genes, and the lack of new classes of compounds indicate the importance of navigating toward more sustainable coevolutionary dynamics between human culture and species that evolve resistance. To inform this challenge, we introduce the concept of coevolutionary governance and propose three priorities for its implementation: (i) new norms and mental models for lowering use, (ii) diversifying practices to reduce directional selection, and (iii) investment in collective action institutions to govern connectivity. We highlight the availability of solutions that facilitate broader sustainable development, which for antibiotic resistance include improved sanitation and hygiene, strong health systems, and decreased meat consumption.

中文翻译：

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抗生素和农药抗性的协同进化治理。

新杀生物剂的开发已主导了人类对抗生素和农药抗性进化的反应。越来越普遍地使用杀生物剂，抗药性基因的传播以及新型化合物的缺乏表明了在人类文化与进化抗药性物种之间寻求更可持续的协同进化动力学的重要性。为了应对这一挑战，我们介绍了协同进化治理的概念，并提出了实施它的三个优先事项：（i）减少使用的新规范和思维模式，（ii）减少方向选择的多样化做法，以及（iii）对集体行动的投资机构来管理连通性。我们着重介绍可促进更广泛的可持续发展的解决方案，这些解决方案对抗生素的抵抗力包括改善卫生条件，