Development and validation of accurate and selective spectrophotometric methods were carried out for determination of a new combination of Mebendazole and Quinfamide in bulk powder and pharmaceutical formulation. Extended ratio subtraction coupled with isoabsorptive point methods were used for determination of the binary mixture. A comparative study was carried out between the newly developed methods; simultaneous ratio subtraction, absorbance subtraction, and dual wavelength spectrophotometric methods were applied as well. The developed methods were validated in accordance with the ICH guidelines. The developed methods were successfully carried out for determination of Quinfamide and Mebendazole in Vermox Plus® tablets. Upon statistical comparison of the results obtained by the developed methods with those obtained by the reported simultaneous equation spectrophotometric method, no significant difference was shown among them. Moreover, the introduced methods have the advantages of being more sensitive and have wider linearity ranges than other reported spectrophotometric methods.

中文翻译：

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环保分光光度法准确定量甲苯达唑和奎尼酰胺组合的比较研究；内容一致性评估。

进行了准确和选择性分光光度法的开发和验证，以确定散装粉末和药物制剂中甲苯达唑和奎尼酰胺的新组合。扩展比率减法与等吸收点法相结合用于确定二元混合物。新开发的方法之间进行了比较研究。同时应用了比率减法，吸光度减法和双波长分光光度法。所开发的方法已按照ICH指南进行了验证。成功地执行了开发的方法，用于测定VermoxPlus®片剂中的奎尼酰胺和甲苯达唑。在对通过开发的方法获得的结果与通过报告的联立方程分光光度法获得的结果进行统计比较时，在它们之间没有显示出显着差异。此外，与其他已报道的分光光度法相比，引入的方法具有灵敏度更高和线性范围更广的优点。