Cerium doped magnetite nanoparticle (CDM) was synthesized via a co-precipitation method and used as the co-reactant of luminol-K₃Fe(CN)₆ chemiluminescent system. The physical-chemical features of CDM were studied by XPS, XRD, HRTEM, FESEM, VSM, BET, and FTIR analyses. This simple and highly sensitive nanoprobe enabled the determination of minor concentrations of metronidazole (MNZ). Owing to the quenching efficacy of MNZ in the studied chemiluminescence system, a linear range of 3.47 × 10⁻⁶-9.37 × 10⁻⁵ mol/L was obtained with a limit of detection of 3.91 × 10⁻⁷ mol/L. This biosensor was used for MNZ detection in human serum samples, which was highly efficient. The outcomes of this study give credit to the proposed biosensor to be applied for detection of MNZ in biological samples.

通过共沉淀法合成了铈掺杂磁铁矿纳米粒子（CDM），并用作鲁米诺-K ₃ Fe（CN）₆化学发光体系的共反应物。通过XPS，XRD，HRTEM，FESEM，VSM，BET和FTIR分析研究了CDM的物理化学特征。这种简单且高度灵敏的纳米探针能够测定微量的甲硝唑（MNZ）。由于在研究的化学发光系统中MNZ的猝灭功效，线性范围为3.47×10 ^-6 -9.37×10 ^-5  mol / L，检出限为3.91×10 ^-7 摩尔/升。该生物传感器用于人类血清样品中的MNZ检测，效率很高。这项研究的成果使拟议的生物传感器可用于检测生物样品中的MNZ。