Encapsulation of a persuasive anticancer drug (Sanguinarine, SGR) within microheterogeneous environment of niosome has been investigated. Utilizing steady-state and time-resolved spectroscopic methods the effects of extrinsically added salts and temperature on the photophysical properties of niosome-bound bio-active drug have been explored thoroughly. The prototropic (alkanolamine⇌ iminium) equilibrium of SGR is found to be preferentially favored toward the neutral form inside the hydrophobic interior of niosome. With addition of salts and increment of temperature the reverse tendency of stabilization of the cationic species is observed which can be explained on the basis of degree of water penetration of water molecules to the hydration layer of niosome. Furthermore, drug sequestration has been investigated via disruption of niosome applying cyclodextrins (CDs). Exploration of the effect of CDs (β-CD and γ-CD) on the niosome aids to have knowledge of the effect of CDs on cell membrane. In addition, the differential rotational relaxation behavior of SGR at various environmental circumstances has been observed to substantiate with other experimental results.

已经研究了将有说服力的抗癌药（Sanguinarine，SGR）包裹在脂质体的微非均质环境中。利用稳态和时间分辨光谱方法，已充分探索了外加盐和温度对与脂质体结合的生物活性药物的光物理性质的影响。发现SGR的质子（烷醇胺⇌亚胺）平衡优先朝着Niosome疏水内部的中性形式倾斜。随着盐的添加和温度的升高，观察到阳离子物质稳定的相反趋势，这可以根据水分子向脂质体的水合层的水渗透程度来解释。此外，已经通过应用环糊精（CD）破坏脂质体来研究药物螯合。探索CD（β-CD和γ-CD）对脂质体的作用有助于了解CD对细胞膜的作用。另外，已经观察到SGR在各种环境条件下的不同的旋转弛豫行为可以用其他实验结果证实。