p62/SQSTM1 (hereafter as p62) is a stress-inducible cellular protein, which interacts with various signaling proteins to regulate a variety of cellular functions. Growing lines of evidence supported a critical role of p62 in tumorigenesis, and p62 may become a therapeutic target for tumor. In this review, we summarize biological functions of structural domains of p62, reported bioactive molecules targeting p62, and the relationship between p62 and tumorigenesis.

中文翻译：

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p62作为肿瘤的治疗靶标

p62 / SQSTM1（以下称为p62）是一种压力诱导型细胞蛋白，可与多种信号蛋白相互作用以调节多种细胞功能。越来越多的证据支持p62在肿瘤发生中的关键作用，p62可能成为肿瘤的治疗靶标。在这篇综述中，我们总结了p62结构域的生物学功能，报道的靶向p62的生物活性分子以及p62与肿瘤发生之间的关系。