A metal-free approach to polysubstituted oxazoles via the oxidative coupling of readily available benzylamines and 1,3-dicarbonyl derivatives in the presence of an external base has been developed. A variety of functional groups on both of the starting materials are tolerated using this method, affording the corresponding oxazoles in moderate to good yields. Iodination was proposed as the initiation step of the reaction and a plausible mechanism has been proposed to explain the reaction pathway.

中文翻译：

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NIS-TBHP促进CN和CO键的氧化偶联：多金属取代多唑基的方法

已经开发了一种在外部碱存在下通过容易获得的苄胺和1,3-二羰基衍生物的氧化偶合而形成多取代恶唑的无金属方法。使用这种方法可以耐受两种起始原料上的各种官能团，从而以中等至良好的产率提供相应的恶唑。碘化被提出作为反应的起始步骤，并且提出了一个合理的机理来解释反应途径。