Cognitive impairment is a common and frequently under-recognized complication of chronic kidney disease (CKD). Although there is extensive literature on cognitive interventions that can ameliorate cognitive impairment or associated negative outcomes in the general literature, the breadth and characteristics of cognitive interventions that have been studied in people with CKD are currently unclear. The objective of this scoping review is to identify and describe the literature on cognitive interventions for adults with CKD, including end-stage kidney disease (ESKD). A scoping review following Joanna Briggs Institute methodology will be conducted. With assistance from an information specialist, we will search 5 electronic databases (MEDLINE [OVID], EMBASE, PsycINFO, Cochrane Central Register of Controlled Trials, and CINAHL Plus) using search terms that represent the target population (CKD) and concept (cognition), and conduct backward citation searching for additional literature. Eligible sources will be primary research studies (quantitative or qualitative) that investigate any intervention targeting cognition in adults (≥ 18 years) with CKD or ESKD, including those treated with dialysis. We will extract data about characteristics of interventions (e.g., type, underlying theory, design, location, and provider), populations (e.g., stage of CKD, age, sex, and type of cognitive impairment), and studies (e.g., authors, location, design, and reported findings). Article screening and data extraction will be performed by two to three reviewers. Data will be analyzed using descriptive statistics and narrative syntheses to characterize the literature on cognitive interventions for people with CKD. This study will provide a comprehensive overview of the cognitive interventions that have been studied for people with CKD. It will help identify research gaps within this population (e.g., types of interventions that have yet to be investigated; best practices in cognition research that have not been implemented) and inform the direction of future research in this field.

中文翻译：

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成人慢性肾脏病的认知干预：方案范围审查

认知障碍是慢性肾脏病（CKD）的常见且经常被人们认识不到的并发症。尽管在一般文献中有大量有关认知干预的文献可以缓解认知障碍或相关的负面结果，但是目前尚不清楚在CKD患者中研究的认知干预的广度和特征。范围界定研究的目的是确定和描述有关CKD成人（包括终末期肾脏疾病（ESKD））的认知干预的文献。将根据乔安娜·布里格斯研究所的方法进行范围界定审查。在信息专家的协助下，我们将搜索5个电子数据库（MEDLINE [OVID]，EMBASE，PsycINFO，Cochrane对照试验中央注册，和CINAHL Plus）使用代表目标人群（CKD）和概念（认知）的搜索字词，并进行向后引文搜索以查找其他文献。符合条件的来源将是主要研究（定量或定性），以研究成人（≥18岁）患有CKD或ESKD（包括透析治疗）的任何针对认知的干预措施。我们将提取有关干预措施特征（例如类型，基础理论，设计，位置和提供者），人群（例如CKD的阶段，年龄，性别和认知障碍类型）和研究（例如作者，位置，设计和报告的发现）。文章筛选和数据提取将由两到三名审稿人进行。将使用描述性统计和叙述综合分析数据，以表征有关CKD患者认知干预的文献。这项研究将全面概述已针对CKD患者进行的认知干预。这将有助于确定这一人群中的研究差距（例如，尚待调查的干预类型；尚未实施的认知研究最佳实践），并为该领域的未来研究指明方向。