In sub-Saharan Africa, malaria continues to scourge the population and is the primary cause of morbidity and mortality in young children and pregnant women. As current preventative measures such as intermittent preventive treatment and use of insecticide-treated nets provide incomplete protection, several malaria vaccines are currently under development, including one to specifically prevent pregnancy malaria. Prior to conducting vaccine trials, it is important to obtain background information on poor pregnancy outcomes in the target population to establish a baseline. Pregnant women presenting at community health care centers for antenatal care were recruited to the study. Gestational age was determined by ultrasound examination following recruitment. Antenatal care and pregnancy outcome information were collected during a visit 4–8 weeks post-delivery. One thousand eight hundred fifty women completed the study, and analysis included 1814 women after excluding multiple gestations (n = 26) and missing/incomplete data (n = 10). The percentage (95% CI) of adverse pregnancy outcomes is as follows: miscarriage, 0.28% (0.04–0.52); stillbirth, 1.93% (1.30–2.56); early neonatal death, 1.65% (1.03–2.24); late neonatal death, 0.39%, (0.10–0.68); and preterm delivery (PTD), 4.74% (3.76–5.73). The percentages of early and late neonatal deaths and PTD were significantly higher (p < 0.01) in primigravid compared to multigravid women. In primigravidae, 3.1, 1.1 and 7.1% of pregnancies resulted in early neonatal death, late neonatal death and PTD, respectively, while these outcomes in multigravidae were 1.0, 0.1 and 2.7%, respectively. Major malformations were identified in 4 newborns. Low gravidity and young age predict perinatal death and PTD. The information collected here can be used as a baseline for adverse pregnancy outcomes in future vaccine trials in pregnant women.

中文翻译：

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马里瓦埃勒布古的产前诊所就诊的妇女中不良妊娠结局

在撒哈拉以南非洲，疟疾继续困扰着人口，是幼儿和孕妇发病和死亡的主要原因。由于目前的预防措施（例如间歇性预防性治疗和使用经杀虫剂处理的蚊帐）提供的保护不充分，因此目前正在开发几种疟疾疫苗，包括一种专门预防妊娠疟疾的疫苗。在进行疫苗试验之前，重要的是要获得目标人群中不良妊娠结局的背景信息以建立基线。招募了参加社区卫生保健中心进行产前检查的孕妇。征募后通过超声检查确定妊娠年龄。在分娩后4-8周的访视期间收集了产前护理和妊娠结局信息。一百八十五名妇女完成了这项研究，分析包括1814名妇女，他们排除了多次妊娠（n = 26）和数据缺失/不完整（n = 10）。不良妊娠结局的百分比（95％CI）如下：流产为0.28％（0.04-0.52）；死胎，1.93％（1.30–2.56）；新生儿早期死亡，1.65％（1.03-2.24）；新生儿晚期死亡，0.39％，（0.10–0.68）；早产（PTD）为4.74％（3.76-5.73）。与多重孕妇相比，初重孕妇的早期和晚期新生儿死亡和PTD的百分比显着更高（p <0.01）。在初孕妇中，分别有3.1％，1.1％和7.1％的孕妇分别导致早期新生儿死亡，晚期新生儿死亡和PTD，而在多妊娠中这些结果为1。分别为0、0.1和2.7％。在4个新生儿中发现了主要畸形。低妊娠率和低年龄预测围产期死亡和PTD。此处收集的信息可用作孕妇未来疫苗试验中不良妊娠结局的基线。