This study was conducted to provide evidence on the current status of breast cancer and its incidence trend in Eastern Mediterranean Region during 1998–2019. Also, this study aimed to investigate the association between the incidence of breast cancer and Human Development Index and some factors related to this index, including total fertility rate, and obesity, using a meta-analysis. Data on incidence of breast cancer were collected from various sources, including PubMed, Embase, Web of Science, and WHO, from 1998 to 2019 using systematic review and meta-analysis. Pooled age standardized rate was calculated based on study duration and quality of data using a subgroup analysis and random effect meta-analysis. A total of 80 studies (545 data points) were analyzed. Pooled age standardized rate of breast cancer for Eastern Mediterranean Region was 37.1 per 100,000 person-year (95% confidence interval [CI], 34.5, 39.8) during 2011–2019. age standardized rate of breast cancer had an upward trend in Eastern Mediterranean Region from 2005 to 2019. However, the increasing trend was found to be slightly different in various regions based on quality of data. Moreover, pooled age standardized rate had a significant association with Human Development Index [− 89.2 (95% CI, − 119.8, − 58.7)] and obesity [1.2 (95% CI, 0.9, 1.5)]. Pooled age standardized rate of breast cancer in Eastern Mediterranean Region was lower than the global average. Also, the age standardized rate value and its incremental trend have been higher in countries with high-quality data than in other countries of this region in recent years. Data quality or physiological factors, such as increase in obesity rates, could be the reasons for this incremental trend.

中文翻译：

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1998年至2019年地中海东部地区女性乳腺癌的发病趋势：系统评价和荟萃分析。

这项研究的目的是提供证据，说明1998-2019年间东地中海地区乳腺癌的现状及其发病趋势。此外，本研究旨在通过荟萃分析研究乳腺癌发病率与人类发展指数以及与该指数相关的一些因素之间的关联，其中包括总生育率和肥胖。使用系统评价和荟萃分析，从1998年至2019年从各种来源收集了乳腺癌发病率数据，包括PubMed，Embase，Web of Science和WHO。使用亚组分析和随机效应荟萃分析，根据研究持续时间和数据质量计算合并年龄标准化率。总共分析了80个研究（545个数据点）。东地中海地区的合并年龄标准化乳腺癌率为37。2011-2019年期间，每100,000人年1个（95％置信区间[CI]，34.5、39.8）。从2005年到2019年，地中海东部地区年龄标准化乳腺癌的发病率呈上升趋势。但是，根据数据质量，发现各个地区的上升趋势略有不同。此外，合并年龄标准化率与人类发展指数[− 89.2（95％CI，-119.8，− 58.7）]和肥胖症[1.2（95％CI，0.9，1.5）]显着相关。东地中海地区的乳腺癌合并年龄标准化率低于全球平均水平。此外，近年来，在具有高质量数据的国家中，年龄标准化率值及其增长趋势一直高于该地区的其他国家。数据质量或生理因素，例如肥胖率上升，