当前位置: X-MOL 学术BMC Cardiovasc. Disord. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The association between anthropometric measures of adiposity and the progression of carotid atherosclerosis
BMC Cardiovascular Disorders ( IF 2.1 ) Pub Date : 2020-03-17 , DOI: 10.1186/s12872-020-01417-0
Yume Imahori , Ellisiv B. Mathiesen , Katy E. Morgan , Chris Frost , Alun D. Hughes , Laila A. Hopstock , Stein Harald Johnsen , Nina Emaus , David A. Leon

Few reports are available on the contribution of general and abdominal obesity to the progression of carotid atherosclerosis in late adulthood. This study investigated the impact of four simple anthropometric measures of general and abdominal obesity on the progression of carotid atherosclerosis and the extent to which the association between adiposity and the progression of plaque burden is mediated by cardiometabolic markers. Four thousand three hundred forty-five adults (median age 60) from the population-based Tromsø Study were followed over 7 years from the first carotid ultrasound screening to the next. The progression of carotid atherosclerosis was measured in three ways: incidence of plaques in previously plaque-free participants; change in the number of plaques; and total plaque area (TPA). We used generalised linear models to investigate the association between each adiposity measure – body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) – and each outcome. Models were adjusted for potential confounders (age, sex, smoking, education, physical activity). The pathways through which any associations observed might operate were investigated by further adjusting for cardiometabolic mediators (systolic blood pressure, cholesterol, and HbA1c). There was little evidence that adiposity was related to the formation of new plaques during follow-up. However, abdominal adiposity was associated with TPA progression. WHtR showed the largest effect size (mean change in TPA per one standard deviation (SD) increase in WHtR of 0.665 mm2, 95% confidence interval 0.198, 1.133) while BMI showed the smallest. Effect sizes were substantially reduced after the adjustment for potential mediators. Abdominal obesity indirectly measured with WC seems more strongly associated with the progression of TPA than general obesity. These associations appear to be largely mediated by known cardiometabolic markers.

中文翻译:

肥胖的人体测量指标与颈动脉粥样硬化进展之间的关联

关于成年人和腹部肥胖对成年晚期颈动脉粥样硬化进展的贡献的报道很少。这项研究调查了普通肥胖和腹部肥胖的四种简单的人体测量学方法对颈动脉粥样硬化进展的影响以及通过心脏代谢指标介导肥胖与斑块负荷进展之间的关联的程度。从基于人群的Tromsø研究中,共有435位成年人(中位年龄为60岁)在从第一次颈动脉超声筛查到下一次的7年间进行了随访。用三种方法测量颈动脉粥样硬化的进展:以前无斑块的参与者的斑块发生率;改变噬菌斑数量;和总菌斑面积(TPA)。我们使用广义线性模型研究了每个肥胖测量指标(体重指数(BMI),腰围(WC),腰臀比(WHR)和腰围身高比(WHtR))之间的关联-结果。针对潜在的混杂因素(年龄,性别,吸烟,教育,体育锻炼)对模型进行了调整。通过进一步调整心脏代谢介质(收缩压,胆固醇和HbA1c)来研究观察到的任何关联可能通过的途径。几乎没有证据表明肥胖与随访期间新斑块的形成有关。但是,腹部肥胖与TPA进展相关。WHtR表现出最大的效应大小(WHtR每增加一个标准偏差(SD),TPA的平均变化为0.665 mm2,95%置信区间0.198,1。133),而BMI最小。调整潜在的介体后,效应的大小大大减少。与普通肥胖症相比,用WC间接测量的腹部肥胖症似乎与TPA的进展更紧密相关。这些关联似乎主要由已知的心脏代谢指标介导。
更新日期:2020-03-19
down
wechat
bug