The Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation for Men (LIFTMOR‐M) trial examined efficacy and safety of two novel exercise programs in older men with low BMD. Men with low hip and/or LS BMD were randomized to high‐intensity progressive resistance and impact training (HiRIT) or machine‐based isometric axial compression (IAC) and compared to a nonrandomized matched control (CON). Outcomes included: hip and LS BMD; calcaneal ultrasound parameters; anthropometry; body composition; function (timed up‐and‐go [TUG], five‐times sit‐to‐stand [FTSTS]); back extensor strength (BES); leg extensor strength (LES); compliance and adverse events. Ninety‐three men (67.1 ± 7.5 years; 82.1 ± 11.6 kg; 175.2 ± 6.7 cm; FN T‐score −1.6 ± 0.6) were randomized to HiRIT (n = 34) or IAC (n = 33), or allocated to CON (n = 26). HiRIT improved trochanteric BMD (2.8 ± 0.8%; −0.1 ± 0.9%, p = .024), LS BMD (4.1 ± 0.7%; 0.9 ± 0.8%, p = .003), BUA (2.2 ± 0.7%; −0.8 ± 0.9%, p = .009), stiffness index (1.6 ± 0.9%; −2.0 ± 1.1%, p = .011), lean mass (1.5 ± 0.8%; −2.4 ± 0.9%, p = .002), TUG, FTSTS, BES, and LES (p < .05) compared with CON. IAC improved lean mass (0.8 ± 0.8%; −2.4 ± 0.9%, p = .013) and FTSTS (−4.5 ± 1.6%; 7.5 ± 2.0%, p < .001) compared with CON. HiRIT improved LS BMD (4.1 ± 0.7%; 2.0 ± 0.7%, p = .039), stiffness index (1.6 ± 0.9%; −1.3 ± 0.9%, p = .025), and FTSTS (−10.7 ± 1.6%; −4.5 ± 1.7%, p = .010) compared with IAC. Exercise compliance was high (HiRIT 77.8 ± 16.6%; IAC 78.5 ± 14.8%, p = .872). There were five minor adverse events (HiRIT, 2; IAC, 3). HiRIT was well‐tolerated and improved bone, function and fracture risk more than CON or IAC. © 2020 American Society for Bone and Mineral Research.

中文翻译：

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降低骨量减少和骨质疏松的中老年男性骨折风险的骨靶向运动策略比较：LIFTMOR-M半随机对照试验。

男性锻炼肌肉和骨质疏松康复训练的解除干预（LIFTMOR-M）试验检查了两种新的锻炼计划对低BMD老年男性患者的疗效和安全性。低髋部和/或LS BMD的男性被随机分配至高强度进行性抵抗训练和冲击训练（HiRIT）或基于机器的等轴测轴向压缩（IAC），并与非随机匹配对照（CON）进行比较。结果包括：髋部和LS BMD；跟骨超声参数; 人体测量学 身体构成; 功能（定时[TUG]，五次坐姿[FTSTS]）；背伸肌力量（BES）; 腿伸肌力量（LES）; 依从性和不良事件。九十三名男性（67.1±7.5岁; 82.1±11.6 kg; 175.2±6.7 cm; FN T评分-1.6±0.6）被随机分为HiRIT（n = 34）或IAC（n= 33），或分配给CON（n = 26）。HiRIT改良股骨转子骨BMD（2.8±0.8％; -0.1±0.9％，p = .024），LS BMD（4.1±0.7％; 0.9±0.8％，p = 0.003），BUA（2.2±0.7％; -0.8 ±0.9％，p = .009），刚度指数（1.6±0.9％; -2.0±1.1％，p = .011），瘦质量（1.5±0.8％; -2.4±0.9％，p = .002）， TUG，FTSTS，BES和LES（p <.05）与CON相比。与CON相比，IAC改善了瘦肉质量（0.8±0.8％; -2.4±0.9％，p = .013）和FTSTS（-4.5±1.6％; 7.5±2.0％，p <.001）。HiRIT改善了LS BMD（4.1±0.7％; 2.0±0.7％，p = .039），刚度指数（1.6±0.9％; -1.3±0.9％，p= .025）和FTSTS（−10.7±1.6％; −4.5±1.7％，p = .010）。运动依从性很高（HiRIT 77.8±16.6％; IAC 78.5±14.8％，p = .872）。有五个轻微不良事件（HiRIT，2； IAC，3）。与CON或IAC相比，HiRIT具有良好的耐受性，并改善了骨骼，功能和骨折风险。©2020美国骨骼和矿物质研究学会。