There is limited evidence regarding a possible association between exposure to ambient air pollutants and the risk of non‐Hodgkin lymphoma (NHL). Previous epidemiological studies have relied on crude estimations for air pollution exposure and/or small numbers of NHL cases. The objective of our study was to analyze this association based on air pollution modeled at the address level and NHL cases identified from the nationwide Danish Cancer Registry. We identified 20,874 incident NHL cases diagnosed between 1989 and 2014 and randomly selected 41,749 controls matched on age and gender among the entire Danish population. We used conditional logistic regression to estimate odds ratios (ORs) and adjusted for individual and neighborhood level sociodemographic variables. There was no association between exposure to PM_2.5, BC, O₃, SO₂ or NO₂ and overall risk of NHL but several air pollutants were associated with higher risk of follicular lymphoma, but statistically insignificant, for example, PM_2.5 (OR = 1.15 per 5 μg/m³; 95% CI: 0.98–1.34) and lower risk for diffuse large B‐cell lymphoma (OR = 0.92 per 5 μg/m³; 95% CI: 0.82–1.03). In this population‐based study, we did not observe any convincing evidence of a higher overall risk for NHL with higher exposure to ambient air pollutants.

中文翻译：

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丹麦的长期空气污染和非何杰金淋巴瘤的风险：一项基于人群的病例对照研究。

关于暴露于环境空气污染物与非霍奇金淋巴瘤（NHL）风险之间可能存在关联的证据有限。以前的流行病学研究依赖于空气污染暴露和/或少数NHL病例的粗略估计。我们研究的目的是基于在地址级别建模的空气污染和从全国丹麦癌症登记处确定的NHL病例来分析这种关联。我们确定了1989年至2014年之间诊断的20874例NHL突发事件，并在整个丹麦人群中随机选择了41749例年龄和性别相符的对照。我们使用条件逻辑回归来估计比值比（OR），并针对个人和邻里水平的社会人口统计学变量进行了调整。PM _2.5暴露之间没有关联，BC，O ₃，SO ₂或NO ₂以及NHL的总体风险，但几种空气污染物与滤泡性淋巴瘤的更高风险相关，但统计学上无关紧要，例如PM _2.5（OR = 1.15每5μg/ m ³； 95 ％CI：0.98–1.34）和较低的弥散性大B细胞淋巴瘤风险（OR = 0.92每5μg/ m ³； 95％CI：0.82-1.03）。在这项基于人群的研究中，我们没有观察到任何令人信服的证据，即暴露于环境空气污染物中的NHL总体风险更高。