In this study, the molecularly imprinted nano-polymer of minocycline was polymerized on the surface of a metal organic framework material to synthesize a novel composite. This composite was used as absorbent to develop a dispersive solid phase microextraction method for extraction of 7 tetracyclines in chicken muscle followed by determination with ultra performance liquid chromatography. The composite achieved high absorption capacities (2200–3000 ng/mg) and high recoveries (> 92%) for the 7 tetracyclines, and could be reused for 8 times. Due to the high enrichment factors (18–37), the limits of detection for the 7 drugs were in the range of 0.2–0.6 ng/g, and the limits of quantification were in the range of 0.5–2.0 ng/g. The recoveries of the 7 drugs from standard-fortified blank chicken muscle sample were in the range of 69.6–94.7%. Therefore, this method could be used as a practical tool for multi-detection of the residues of tetracyclines in meat.

在这项研究中，将米诺环素的分子印迹纳米聚合物聚合在金属有机骨架材料的表面上，以合成新型复合材料。将该复合材料用作吸收剂，开发了一种分散固相微萃取方法，用于提取鸡肉中的7种四环素，然后用超高效液相色谱法进行测定。该复合材料对7种四环素具有很高的吸收能力（2200–3000 ng / mg）和高回收率（> 92％），可以重复使用8次。由于高富集因子（18-37），这7种药物的检出限在0.2-0.6 ng / g范围内，而定量限在0.5-2.0 ng / g范围内。从标准强化的空白鸡肌肉样品中提取的7种药物的回收率在69.6–94.7％之间。因此，