Regulated fear and extinction memory is essential for balanced behavioral response. Limbic brain regions are susceptible to hypobaric hypoxia (HH) and are putative target for fear extinction deficit and dysregulation. The present study aimed to examine the effect of HH and extract (GBE) on fear and extinction memory with the underlying mechanism. Adult male Sprague-Dawley rats were evaluated for fear extinction and anxious behavior following GBE administration during HH exposure. Blood and tissue (PFC, hippocampus and amygdala) samples were collected for biochemical, morphological and molecular studies.

中文翻译：

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低压缺氧引起的恐惧和消退记忆障碍以及银杏叶的改善作用：行为、神经化学和分子相关性

调节恐惧和灭绝记忆对于平衡的行为反应至关重要。边缘脑区域容易受到低压缺氧（HH）的影响，并且是恐惧消退缺陷和失调的假定目标。本研究旨在探讨 HH 和提取物 (GBE) 对恐惧和消退记忆的影响及其潜在机制。在 HH 暴露期间给予 GBE 后，评估成年雄性 Sprague-Dawley 大鼠的恐惧消退和焦虑行为。收集血液和组织（PFC、海马和杏仁核）样本用于生化、形态学和分子研究。