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Magnetic resonance spectroscopy studies in subjects with high risk for psychosis: A meta-analysis and review.
Journal of Psychiatric Research ( IF 4.8 ) Pub Date : 2020-03-16 , DOI: 10.1016/j.jpsychires.2020.03.006
Bruno Romeo 1 , Amelie Petillion 1 , Catherine Martelli 2 , Amine Benyamina 1
Affiliation  

INTRODUCTION Even though anomalies on brain metabolites have been found in schizophrenia, researches about subjects with high risk (HR) show heterogeneous results. Thus, this meta-analysis aims to characterize the metabolic profile of HR subjects, first, compared to controls (HC) and then compared to people with schizophrenia. METHODS After a systematic database search, means and standard deviations were extracted to calculate standardized mean differences (SMD). Cerebral metabolites levels were compared between HR subjects and HC or patients with schizophrenia in all regions of interest investigated in included studies. Meta-regressions were performed to explore the influence of demographic and clinical variables on metabolites level's SMDs. RESULTS Thirty-nine studies were included in this meta-analysis. A higher level of glutamine + glutamate (Glx) was found in the medial prefrontal cortex (mPFC) (p < 0.01) and potentially in the basal ganglia (p = 0,05) as well as a higher level of myo-inositol (mI) in the dorsolateral prefrontal cortex (DLPFC) (p = 0.04) in HR subjects compared to HC. A higher level of choline (Cho) was found in people with schizophrenia compared to HR subjects in the DLPFC (p < 0.001) and the medial temporal lobe (p = 0.02). Meta-regression analyses showed negative associations between SMD for Cho concentration, the percentage of females or the age (p = 0.01). CONCLUSIONS The present meta-analysis provides evidence that some brain metabolites concentrations are disrupted before the transition to psychosis and could be considered like a vulnerability.

中文翻译:

精神病高危人群的磁共振波谱研究:一项荟萃分析和综述。

引言即使在精神分裂症中发现脑代谢物异常,对高危受试者的研究也显示出异质的结果。因此,这项荟萃分析旨在表征HR受试者的代谢特征,首先将其与对照(HC)进行比较,然后与精神分裂症患者进行比较。方法经过系统的数据库搜索后,提取均值和标准差以计算标准化均值差(SMD)。在纳入研究中,比较了所有受关注地区的HR受试者和HC或精神分裂症患者的脑代谢物水平。进行了荟萃回归,以探讨人口统计学和临床​​变量对代谢物水平的SMD的影响。结果该荟萃分析包括三十九项研究。在内侧前额叶皮层(mPFC)(p <0.01)和潜在的基底神经节(p = 0,05)中发现了更高水平的谷氨酰胺+谷氨酸(Glx),以及更高水平的肌醇(mI)被发现HR受试者的背外侧前额叶皮质(DLPFC)(p = 0.04)与HC相比)。与DLPFC(p <0.001)和颞中叶(p = 0.02)的HR受试者相比,精神分裂症患者的胆碱(Cho)水平更高。荟萃回归分析显示,SMD与Cho浓度,女性百分比或年龄之间呈负相关(p = 0.01)。结论本荟萃分析提供了证据,表明某些脑代谢物的浓度在转变为精神病之前被破坏,可以被视为一种脆弱性。01),与HC相比,HR受试者可能在基底神经节(p = 0,05)以及背外侧前额叶皮层(DLPFC)中较高水平的肌醇(mI)(p = 0.04)。与DLPFC(p <0.001)和颞中叶(p = 0.02)的HR受试者相比,精神分裂症患者的胆碱(Cho)水平更高。荟萃回归分析显示,SMD与Cho浓度,女性百分比或年龄之间呈负相关(p = 0.01)。结论本荟萃分析提供了证据,表明某些脑代谢物的浓度在转变为精神病之前被破坏,可以被视为一种脆弱性。01),与HC相比,HR受试者可能在基底神经节(p = 0,05)以及背外侧前额叶皮层(DLPFC)(p = 0.04)中较高水平的肌醇(mI)。与DLPFC(p <0.001)和颞中叶(p = 0.02)的HR受试者相比,精神分裂症患者的胆碱(Cho)水平更高。荟萃回归分析显示,SMD与Cho浓度,女性百分比或年龄之间呈负相关(p = 0.01)。结论本荟萃分析提供了证据,表明某些脑代谢物的浓度在转变为精神病之前被破坏,可以被视为一种脆弱性。04)在HR主题中与HC相比。与DLPFC(p <0.001)和颞中叶(p = 0.02)的HR受试者相比,精神分裂症患者的胆碱(Cho)水平更高。荟萃回归分析显示,SMD与Cho浓度,女性百分比或年龄之间呈负相关(p = 0.01)。结论当前的荟萃分析提供了证据,表明某些脑代谢物的浓度在转变为精神病之前被破坏,可以被认为是一种脆弱性。04)在HR主题中与HC相比。与DLPFC(p <0.001)和颞中叶(p = 0.02)的HR受试者相比,精神分裂症患者的胆碱(Cho)水平更高。荟萃回归分析显示,SMD与Cho浓度,女性百分比或年龄之间呈负相关(p = 0.01)。结论当前的荟萃分析提供了证据,表明某些脑代谢物的浓度在转变为精神病之前被破坏,可以被认为是一种脆弱性。
更新日期:2020-03-16
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