Recently, Perrin et al. reported the application of thermal proteome profiling (TPP), a cellular thermal shift assay with an unbiased proteomics readout to complex tissue samples from model organisms and patient-derived whole blood. This study demonstrates for the first time that TPP enables organ-specific drug target engagement and identification studies during the later stages of drug discovery and even in a clinical setting.

中文翻译：

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表征药物-靶标相互作用：向临床转移。

最近，Perrin等。报道了热蛋白质组图谱（TPP）的应用，一种具有无偏蛋白质组学读数的细胞热位移测定法，用于从模型生物和患者来源的全血中提取的复杂组织样品。这项研究首次证明，TPP在药物发现的后期甚至在临床环境中都可以进行器官特异性药物靶标的参与和鉴定研究。