Literature has paid little attention in describing the specific contribution of each modifiable and non-modifiable characteristics on health-related quality of life (HRQoL) in physician-managed anticoagulated patients using vitamin K antagonists (VKAs). To describe how patients’ treatment-specific knowledge, health literacy, treatment beliefs, clinical, and socio-demographic characteristics influence HRQoL in Italian physician-managed anticoagulated patients using VKAs. Cross-sectional multicentre study with a consecutive sampling strategy, enrolling 164 long-term anticoagulated patients. Clinical and socio-demographic characteristics were collected from electronic medical records. Valid and reliable questionnaires were used to collect patients’ treatment-specific knowledge, health literacy, beliefs about VKAs, physical and health perceptions. Obtaining and understanding health information (i.e., communicative health literacy) positively predicts both adequate mental (ORadjusted = 10.9; 95%CI = 1.99–19.10) and physical (ORadjusted = 11.54; 95%CI = 1.99–34.45) health perceptions. Conversely, the ability to perform proper health decision making (i.e., critical health literacy) was associated with lower rates of adequate mental health perception (ORadjusted = 0.13; 95%CI = 0.03–0.63). Further, age negatively predicted physical health perception (ORadjusted = 0.87; 95%CI = 0.81–0.93). Health literacy plays an interesting role in predicting HRQoL. The relationship between critical health literacy and mental health perception could be influenced by some psychological variables, such as distress and frustration, which could be present in patients with higher levels of critical health literacy, as they could be more inclined for self-monitoring. For this reason, future research are needed to identify the most suitable patients’ profile for each OAC-management model, by longitudinally describing the predictive performance of each modifiable and non-modifiable determinant of HRQoL.

中文翻译：

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健康相关生活质量的决定因素：使用维生素K拮抗剂的医师管理的抗凝患者的横断面调查。

在描述使用维生素K拮抗剂（VKA）的医师管理的抗凝患者中，每种可修改和不可修改特征对健康相关生活质量（HRQoL）的具体贡献方面，文献很少关注。描述患者的特定治疗知识，健康素养，治疗信念，临床和社会人口统计学特征如何影响使用VKA的意大利医师管理的抗凝患者的HRQoL。具有连续采样策略的横断面多中心研究招募了164名长期抗凝患者。从电子病历中收集临床和社会人口统计学特征。使用有效且可靠的调查表收集患者的特定治疗知识，健康素养，对VKA的信念，身体和健康观念。获得和理解健康信息（即沟通健康素养）可以积极预测心理（OR调整后= 10.9； 95％CI = 1.99–19.10）和身体（OR调整后= 11.54； 95％CI = 1.99–34.45）的健康感知。相反，进行适当的健康决策的能力（即关键的健康素养）与较低的充分心理健康知觉率相关（OR调整后= 0.13； 95％CI = 0.03-0.63）。此外，年龄对身体健康知觉负面预测（OR调整后= 0.87； 95％CI = 0.81-0.93）。健康素养在预测HRQoL中扮演着有趣的角色。关键健康素养与心理健康知觉之间的关系可能会受到一些心理变量的影响，例如困扰和沮丧，这些变量可能存在于较高的关键健康素养水平的患者中，因为他们可能更倾向于自我监控。因此，需要通过纵向描述HRQoL的每个可修改和不可修改的决定因素的预测性能，来确定每种OAC管理模型最合适的患者资料的未来研究。