The intestinal epithelial barrier allows absorption of dietary nutrients and prevents passage of pathogens and toxins into the body. Severe insults have a negative impact on the intestinal environment, which may decrease intestinal barrier function and cause bacterial translocation. Bacterial translocation, which can cause infectious complications, is defined as the passage of microbes from the gastrointestinal tract across the mucosal barrier to extraintestinal sites. The aim of this study was to investigate the correlation between concentrations of preoperative fecal organic acids and the occurrence of postoperative infectious complications in patients with esophageal cancer. Fifty-five patients with esophageal cancer who underwent esophagectomy were enrolled in this study. Perioperative synbiotics were administered to all patients. Perioperative clinical characteristics and concentrations of preoperative fecal organic acids were compared between patients with and without postoperative infectious complications. Postoperative infectious complications occurred in 10 patients. In patients with complications, the concentrations of acetic acid and propionic acid were significantly lower than in patients without complications (p = 0.044 and 0.032, respectively). The concentration of butyric acid was nonsignificantly lower in patients with complications, while the concentration of lactic acid was nonsignificantly higher. The calculated gap between the concentrations of fecal acetic acid plus propionic acid plus butyric acid minus lactic acid was significantly lower in patients with complications. Multivariate analysis revealed that a low gap between acetic acid plus propionic acid plus butyric acid minus lactic acid was an independent risk factor for postoperative infectious complications (p = 0.027). Preoperative fecal concentrations of organic acids had a clinically important impact on the occurrence of postoperative infectious complications in patients with esophageal cancer. To reduce postoperative infectious complications, it may be useful to modulate the intestinal environment and maintain concentrations of fecal organic acids before surgery.

中文翻译：

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术前粪便短链脂肪酸对食管癌患者术后感染并发症的影响

肠上皮屏障可吸收饮食中的营养，并防止病原体和毒素进入人体。严重的侮辱会对肠道环境产生负面影响，这可能会降低肠道屏障功能并引起细菌移位。细菌易位，可能引起传染性并发​​症，被定义为微生物从胃肠道穿过粘膜屏障到达肠外部位的通道。这项研究的目的是调查食管癌患者术前粪便有机酸浓度与术后感染并发症发生率之间的相关性。这项研究纳入了55例接受食管切除术的食道癌患者。对所有患者进行围手术期合生素治疗。比较有无术后感染并发症的患者的围手术期临床特征和术前粪便有机酸浓度。10例患者发生术后感染并发症。在有并发症的患者中，乙酸和丙酸的浓度明显低于无并发症的患者（分别为p = 0.044和0.032）。并发症患者中丁酸的浓度无明显降低，而乳​​酸的浓度无明显升高。合并症患者的粪便乙酸，丙酸，丁酸和乳酸的浓度之间的计算差距显着降低。多变量分析显示，乙酸+丙酸+丁酸-乳酸之间的低间隙是术后感染并发症的独立危险因素（p = 0.027）。术前粪便中有机酸的浓度对食管癌患者术后感染并发症的发生具有重要的临床意义。为了减少术后感染并发症，在手术前调节肠道环境并保持粪便有机酸浓度可能是有用的。术前粪便中有机酸的浓度对食管癌患者术后感染并发症的发生具有重要的临床意义。为了减少术后感染并发症，在手术前调节肠道环境并保持粪便有机酸浓度可能是有用的。术前粪便中有机酸的浓度对食管癌患者术后感染并发症的发生具有重要的临床意义。为了减少术后感染并发症，在手术前调节肠道环境并保持粪便有机酸浓度可能是有用的。