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Regional Patterns and Association Between Obesity and Hypertension in Africa
Hypertension ( IF 8.3 ) Pub Date : 2020-05-01 , DOI: 10.1161/hypertensionaha.119.14147
Onoja M Akpa 1, 2, 3, 4 , Felix Made 4, 5 , Akinlolu Ojo 6 , Bruce Ovbiagele 7 , Dwomoa Adu 8 , Ayesha A Motala 9 , Bongani M Mayosi 10 , Sally N Adebamowo 11 , Mark E Engel 12 , Bamidele Tayo 13 , Charles Rotimi 14 , Babatunde Salako 1 , Rufus Akinyemi 1 , Mulugeta Gebregziabher 15 , Fred Sarfo 16 , Kolawole Wahab 17 , Godfred Agongo 18 , Marianne Alberts 19 , Stuart A Ali 4 , Gershim Asiki 20 , Romuald P Boua 21 , F Xavier Gómez-Olivé 22 , Felistas Mashinya 19 , Lisa Micklesfield 23 , Shukri F Mohamed 20 , Engelbert A Nonterah 18 , Shane A Norris 23 , Hermann Sorgho 21 , Stephen Tollman 22 , Rulan S Parekh 24 , Chishala Chishala 12 , Kenneth Ekoru 25 , Salina P Waddy 26 , Emmanuel Peprah 27 , George A Mensah 28 , Ken Wiley 29 , Jennifer Troyer 30 , Michèle Ramsay 4 , Mayowa O Owolabi 1 ,
Affiliation  

Supplemental Digital Content is available in the text. Hypertension and obesity are the most important modifiable risk factors for cardiovascular diseases, but their association is not well characterized in Africa. We investigated regional patterns and association of obesity with hypertension among 30 044 continental Africans. We harmonized data on hypertension (defined as previous diagnosis/use of antihypertensive drugs or blood pressure [BP]≥140/90 mmHg/BP≥130/80 mmHg) and obesity from 30 044 individuals in the Cardiovascular H3Africa Innovation Resource across 13 African countries. We analyzed data from population-based controls and the Entire Harmonized Dataset. Age-adjusted and crude proportions of hypertension were compared regionally, across sex, and between hypertension definitions. Logit generalized estimating equation was used to determine the independent association of obesity with hypertension (P value <5%). Participants were 56% women; with mean age 48.5±12.0 years. Crude proportions of hypertension (at BP≥140/90 mmHg) were 47.9% (95% CI, 47.4–48.5) for Entire Harmonized Dataset and 42.0% (41.1–42.7) for population-based controls and were significantly higher for the 130/80 mm Hg threshold at 59.3% (58.7–59.9) in population-based controls. The age-adjusted proportion of hypertension at BP≥140/90 mmHg was the highest among men (33.8% [32.1–35.6]), in western Africa (34.7% [33.3–36.2]), and in obese individuals (43.6%; 40.3–47.2). Obesity was independently associated with hypertension in population-based controls (adjusted odds ratio, 2.5 [2.3–2.7]) and odds of hypertension in obesity increased with increasing age from 2.0 (1.7–2.3) in younger age to 8.8 (7.4–10.3) in older age. Hypertension is common across multiple countries in Africa with 11.9% to 51.7% having BP≥140/90 mmHg and 39.5% to 69.4% with BP≥130/80 mmHg. Obese Africans were more than twice as likely to be hypertensive and the odds increased with increasing age.

中文翻译:

非洲肥胖与高血压之间的区域模式和关联

补充数字内容在文本中可用。高血压和肥胖是心血管疾病最重要的可改变危险因素,但它们的关联在非洲并未得到很好的表征。我们调查了 30044 名非洲大陆人的区域模式和肥胖与高血压的关联。我们统一了来自 13 个非洲国家的心血管 H3Africa 创新资源中 30044 个人的高血压(定义为先前诊断/使用抗高血压药物或血压 [BP]≥140/90 mmHg/BP≥130/80 mmHg)和肥胖的数据. 我们分析了来自基于人群的对照和整个协调数据集的数据。在区域、性别和高血压定义之间比较了年龄调整和粗略的高血压比例。Logit广义估计方程用于确定肥胖与高血压的独立关联(P值<5%)。参与者是 56% 的女性;平均年龄 48.5±12.0 岁。整个协调数据集的高血压(BP≥140/90 mmHg)的粗略比例为 47.9%(95% CI,47.4-48.5),基于人群的对照为 42.0%(41.1-42.7),130/在基于人群的对照中,80 毫米汞柱阈值为 59.3% (58.7–59.9)。BP≥140/90 mmHg 时的年龄调整高血压比例在男性(33.8% [32.1–35.6])、西非(34.7% [33.3–36.2])和肥胖个体(43.6%; 40.3–47.2)。在基于人群的对照中,肥胖与高血压独立相关(调整后的优势比为 2.5 [2.3-2. 7]) 和肥胖症高血压的几率随着年龄的增加而增加,从年轻的 2.0 (1.7-2.3) 到年长的 8.8 (7.4-10.3)。高血压在非洲多个国家很常见,11.9% 至 51.7% 的血压≥140/90 mmHg,39.5% 至 69.4% 的血压≥130/80 mmHg。肥胖的非洲人患高血压的可能性是其他人的两倍多,而且随着年龄的增长,这种可能性也增加了。
更新日期:2020-05-01
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