Key topics in the study of host–microbe interactions—such as the prevention of drug resistance and the exploitation of beneficial effects of bacteria—would benefit from concerted efforts with both mechanistic and evolutionary approaches. But due to differences in intellectual traditions, insights gained in one field rarely benefit the other. Here, we develop a conceptual and analytical framework for the integrated study of host–microbe interactions. This framework partitions the health effects of microbes and the effector molecules they produce into components with different evolutionary implications. It thereby facilitates the prediction of evolutionary responses to inhibition and exploitation of specific molecular mechanisms.

中文翻译：

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扩散和仁慈-剖析微生物毒力和促进健康的机制的框架。

在宿主与微生物相互作用研究中的关键主题，如预防耐药性和利用细菌的有益作用，将得益于机械和进化方法的共同努力。但是由于知识传统的差异，在一个领域中获得的见解很少使另一个领域受益。在这里，我们开发了一个概念和分析框架，用于宿主-微生物相互作用的综合研究。该框架将微生物的健康影响及其产生的效应分子划分为具有不同进化意义的成分。因此，它有助于预测对抑制和利用特定分子机制的进化反应。