Securines A—E, three dimeric diarymethane derivatives (1 —3 ) and two enantiomeric diarymethane derivative monomers (4 and 5 ), were isolated and characterized from the medicinal plant Securidaca inappendiculata . Compounds 1 and 2 are a pair of enantiomeric diarymethane derivative dimers, and compound 3 is a mesomeric diarymethane derivative dimer. Their structures were determined by a combination of spectroscopic data, X‐ray crystallography, electronic circular dichroism (ECD) analysis, and computational ECD calculations. Dimeric compounds 1 —3 showed moderate antiplasmodial activities with IC₅₀ values of 0.9, 1.4, and 1.5 μM, respectively.

中文翻译：

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阑尾小Secur的结构有趣的日记甲烷衍生物

Securines A-E，三二聚体diarymethane衍生物（1 - 3）和两种对映体diarymethane衍生物的单体（4和5），分离并从药用植物，其特征蝉翼。化合物1和2是一对对映二甲基甲烷衍生物二聚体，而化合物3是中消旋二甲基甲烷衍生物二聚体。它们的结构是由光谱数据，X射线晶体学，电子圆二色性（ECD）分析和计算ECD计算确定的。二聚体化合物1 - 3表现出中等的抗血浆活性，IC ₅₀值分别为0.9、1.4和1.5μM。