Insulin resistance is a metabolic state where insulin sensitivity is lower than normal condition and strongly related to type 2 diabetes. However, an in vitro model mimicking insulin resistance is rare and thus screening drugs for insulin resistance severely depends on an in vivo model. Here, to increase anti‐diabetic drug selectivity for humans, 3D ADMSCs and macrophages were co‐cultured with in‐house fabricated co‐culture plates.

中文翻译：

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开发三维体外共培养模型，以提高对人类的药物选择性。

胰岛素抵抗是一种新陈代谢状态，胰岛素敏感性低于正常状态，与2型糖尿病密切相关。然而，模仿胰岛素抵抗的体外模型很少见，因此针对胰岛素抵抗的药物筛选严重依赖于体内模型。在这里，为了增加对人类的抗糖尿病药物选择性，将3D ADMSC和巨噬细胞与内部预制的共培养板共培养。