Obesity is a highly heritable multifactorial disease that places an enormous burden on human health. Its increasing prevalence and the concomitant‐reduced life expectancy has intensified the search for new analytical methods that can reduce the knowledge gap between genetic susceptibility and functional consequences of the disease pathology. Although the influence of genetics and epigenetics has been studied independently in the past, there is increasing evidence that genetic variants interact with environmental factors through epigenetic regulation. This suggests that a combined analysis of genetic and epigenetic variation may be more effective in characterizing the obesity phenotype. To date, limited genome‐wide integrative analyses have been performed. In this review, we provide an overview of the latest findings, advantages, and challenges and discuss future perspectives.

中文翻译：

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通过综合的遗传和表观遗传学分析洞察肥胖的多因果关系。

肥胖是一种高度遗传的多因素疾病，给人类健康带来巨大负担。它的患病率不断提高，预期寿命随之缩短，因此加大了对新分析方法的探索，这些方法可以缩小遗传易感性与疾病病理功能后果之间的知识鸿沟。尽管过去已经独立研究了遗传学和表观遗传学的影响，但是越来越多的证据表明遗传变异通过表观遗传学调控与环境因素相互作用。这表明，遗传和表观遗传变异的综合分析可能在表征肥胖表型方面更为有效。迄今为止，已经进行了有限的全基因组整合分析。在这篇评论中，我们概述了最新发现，优势，