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Comparison of two pore sizes of LAE442 scaffolds and their effect on degradation and osseointegration behavior in the rabbit model.
Journal of Biomedical Materials Research Part B: Applied Biomaterials ( IF 3.4 ) Pub Date : 2020-03-14 , DOI: 10.1002/jbm.b.34607
Julia Augustin 1 , Franziska Feichtner 1 , Anja-Christina Waselau 1 , Stefan Julmi 2 , Christian Klose 2 , Peter Wriggers 3 , Hans Jürgen Maier 2 , Andrea Meyer-Lindenberg 1
Affiliation  

The magnesium alloy LAE442 emerged as a possible bioresorbable bone substitute over a decade ago. In the present study, using the investment casting process, scaffolds of the Magnesium (Mg) alloy LAE442 with two different and defined pore sizes, which had on average a diameter of 400 μm (p400) and 500 μm (p500), were investigated to evaluate degradation and osseointegration in comparison to a ß‐TCP control group. Open‐pored scaffolds were implanted in both greater trochanter of rabbits. Ten scaffolds per time group (6, 12, 24, and 36 weeks) and type were analyzed by clinical, radiographic and μ‐CT examinations (2D and 3D). None of the scaffolds caused adverse reactions. LAE442 p400 and p500 developed moderate gas accumulation due to the Mg associated in vivo corrosion, which decreased from week 20 for both pore sizes. After 36 weeks, p400 and p500 showed volume decreases of 15.9 and 11.1%, respectively, with homogeneous degradation, whereas ß‐TCP lost 74.6% of its initial volume. Compared to p400, osseointegration for p500 was significantly better at week 2 postsurgery due to more frequent bone‐scaffold contacts, higher number of trabeculae and higher bone volume in the surrounding area. No further significant differences between the two pore sizes became apparent. However, p500 was close to the values of ß‐TCP in terms of bone volume and trabecular number in the scaffold environment, suggesting better osseointegration for the larger pore size.

中文翻译:

LAE442 支架的两种孔径比较及其对兔模型中降解和骨整合行为的影响。

十多年前,镁合金 LAE442 成为一种可能的生物可吸收骨替代品。在本研究中,使用熔模铸造工艺,研究了镁 (Mg) 合金 LAE442 的支架,该支架具有两种不同且明确的孔径,平均直径为 400 μm (p400) 和 500 μm (p500),以与 ß-TCP 对照组相比,评估降解和骨整合。开孔支架植入兔的两个大转子。通过临床、影像学和 μ-CT 检查(2D 和 3D)分析每个时间组(6、12、24 和 36 周)和类型的 10 个支架。所有支架均未引起不良反应。由于镁相关的体内腐蚀,LAE442 p400 和 p500 产生了适度的气体积累,这两种孔径从第 20 周开始减少。36周后,p400 和 p500 的体积分别减少 15.9% 和 11.1%,降解均匀,而 ß-TCP 损失了其初始体积的 74.6%。与 p400 相比,p500 的骨整合在术后第 2 周明显更好,因为骨-支架接触更频繁,周围区域的小梁数量更多,骨体积更大。两种孔径之间没有进一步的显着差异变得明显。然而,就支架环境中的骨体积和小梁数量而言,p500 接近 ß-TCP 的值,表明较大孔径具有更好的骨整合。p500 的骨整合在术后第 2 周明显更好,因为骨-支架接触更频繁,周围区域的骨小梁数量更多,骨量更高。两种孔径之间没有进一步的显着差异变得明显。然而,就支架环境中的骨体积和小梁数量而言,p500 接近 ß-TCP 的值,表明较大孔径具有更好的骨整合。p500 的骨整合在术后第 2 周明显更好,因为骨-支架接触更频繁,周围区域的骨小梁数量更多,骨量更高。两种孔径之间没有进一步的显着差异变得明显。然而,就支架环境中的骨体积和小梁数量而言,p500 接近 ß-TCP 的值,表明较大孔径具有更好的骨整合。
更新日期:2020-03-14
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