Helminthiasis is one of the gravest problems worldwide. There is a growing concern on less available anthelmintics and the emergence of resistance creating a major threat to human and livestock health resources. Novel and broad‐spectrum anthelmintics are urgently needed. The free‐living nematode Caenorhabditis elegans could address this issue through automated high‐throughput technologies for the screening of large chemical libraries. This review discusses the strong advantages and limitations for using C elegans as a screening method for anthelmintic drug discovery. C elegans is the best model available for the validation of novel effective drugs in treating most, if not all, helminth infections, and for the elucidation the mode of action of anthelmintic candidates. This review also focuses on available technologies in the discovery of anthelmintics published over the last 15 years with particular attention to high‐throughput technologies over conventional screens. On the other hand, this review highlights how combinatorial and nanomedicine strategies could prolong the use of anthelmintics and control resistance problems.

中文翻译：

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药物发现技术：秀丽隐杆线虫作为驱虫疗法的模型。

蠕虫病是世界上最严重的问题之一。人们越来越关注可用的驱虫药较少以及耐药性的出现对人类和牲畜健康资源造成重大威胁。迫切需要新型的广谱驱虫药。自由生活的线虫秀丽隐杆线虫可以通过自动化高通量技术筛选大型化学库来解决这个问题。本综述讨论了使用秀丽隐杆线虫作为驱虫药物发现的筛选方法的强大优势和局限性。秀丽隐杆线虫是可用于验证治疗大多数（如果不是全部）蠕虫感染的新型有效药物以及阐明候选驱虫剂的作用方式的最佳模型。本综述还重点介绍了过去 15 年发表的发现驱虫药的可用技术，特别关注传统屏幕上的高通量技术。另一方面，这篇综述强调了组合和纳米医学策略如何延长驱虫药的使用和控制耐药性问题。