BACKGROUND Toxoplasma gondii (T. gondii) is an intracellular pathogen that can lead to abortion in pregnant women infected with this parasite. Therefore, the present study aimed to estimate the global seroprevalence of anti-T. gondii antibodies in women who had spontaneous abortion based on the results of published articles and evaluate the relationship between seroprevalence of anti-T. gondii antibodies and abortion via a systematical review and meta-analysis. METHODS Different databases were searched in order to gain access to all studies on the seroprevalence of anti- T. gondii antibodies in women who had spontaneous abortion and association between seroprevalence of anti-T. gondii antibodies and abortion published up to April 25th, 2019. Odds ratio (OR) and the pooled rate seroprevalence of T. gondii with a 95% confidence interval (CI) were calculated using the random effects model. RESULTS In total, 8 cross-sectional studies conducted on 1275 women who had abortion in present pregnancy, 40 cross-sectional studies performed on 9122 women who had a history of abortion, and 60 articles (involving 35 cross-sectional studies including 4436 women who had spontaneous abortion as case and 10398 as control and 25 case-control studies entailing 4656 cases and 3178 controls) were included for the final analyses. The random-effects estimates of the prevalence of anti-T. gondii IgG antibody in women who had abortion in present pregnancy and women who had a history of abortion were 33% (95% CI: 17%-49%) and 43% (95% CI: 27%-60%), respectively. In addition, the pooled OR for anti-T. gondii IgG antibody in cross-sectional and case-control studies among women who had spontaneous abortion were 1.65 (95% CI: 1.31-2.09) and 2.26 (95% CI: 1.56-3.28), respectively. Also, statistical analysis showed that the pooled OR of the risk of anti-T. gondii IgM antibody 1.39 (95% CI: 0.61-3.15) in cross-sectional and 4.33 (95% CI: 2.42-7.76) in case-control studies. CONCLUSION Based on the results of the current study, T. gondii infection could be considered a potential risk factor for abortion. It is recommended to carry out further and more comprehensive investigations to determine the effect of T. gondii infection on abortion to prevent and control toxoplasmosis among pregnant women around the world.

中文翻译：

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自然流产妇女中抗弓形虫抗体的全球血清阳性率：系统评价和荟萃分析。

背景弓形虫（T. gondii）是一种细胞内病原体，感染这种寄生虫的孕妇可导致流产。因此，本研究旨在估计抗 T 菌的全球血清流行率。根据已发表文章的结果，对自然流产妇女中的弓形虫抗体进行检测，并评估抗弓形虫血清阳性率之间的关系。通过系统评价和荟萃分析了解弓形虫抗体和堕胎。方法 检索不同的数据库，以获得关于自然流产妇女中抗弓形虫抗体血清阳性率以及抗弓形虫血清阳性率之间关联的所有研究。截至 2019 年 4 月 25 日发布的弓形虫抗体和堕胎。使用随机效应模型计算了弓形虫的比值比 (OR) 和 95% 置信区间 (CI) 的合并血清阳性率。结果 总共对 1275 名当前怀孕期间曾堕胎的妇女进行了 8 项横断面研究，对 9122 名有堕胎史的妇女进行了 40 项横断面研究，并发表了 60 篇文章（涉及 35 项横断面研究，包括 4436 名有过流产史的妇女）。最终分析纳入自然流产病例和 10398 例对照，以及 25 项病例对照研究（4656 例病例和 3178 例对照）。抗 T 蛋白流行率的随机效应估计。目前妊娠中曾流产过的女性和有过流产史的女性中弓形虫 IgG 抗体的比例分别为 33%（95% CI：17%-49%）和 43%（95% CI：27%-60%）。此外，抗 T 的合并 OR。在自然流产妇女的横断面和病例对照研究中，弓形虫 IgG 抗体分别为 1.65 (95% CI: 1.31-2.09) 和 2.26 (95% CI: 1.56-3.28)。此外，统计分析表明，抗 T 风险的汇总 OR。弓形虫 IgM 抗体在横断面研究中为 1.39（95% CI：0.61-3.15），在病例对照研究中为 4.33（95% CI：2.42-7.76）。结论 根据目前的研究结果，弓形虫感染可被认为是流产的潜在危险因素。建议开展进一步、更全面的调查，以确定弓形虫感染对流产的影响，以预防和控制世界各地孕妇弓形体病。