Cardiac dysfunction is a prevalent comorbidity of disrupted inflammatory homeostasis observed in conditions such as sepsis (acute) or obesity (chronic). Secreted and transmembrane protein 1a (Sectm1a) has previously been implicated to regulate inflammatory responses, yet its role in inflammation-associated cardiac dysfunction is virtually unknown.

中文翻译：

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Sectm1a 缺陷通过破坏巨噬细胞中的 LXRα 信号而加重炎症引发的心脏功能障碍

心脏功能障碍是脓毒症（急性）或肥胖（慢性）等疾病中观察到的炎症稳态破坏的常见合并症。分泌跨膜蛋白 1a (Sectm1a) 此前曾被认为与调节炎症反应有关，但其在炎症相关心脏功能障碍中的作用实际上尚不清楚。