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The role of noncoding RNAs in epithelial cancer
Cell Death Discovery ( IF 7 ) Pub Date : 2020-03-12 , DOI: 10.1038/s41420-020-0247-6
Massimiliano Agostini 1 , Carlo Ganini 1 , Eleonora Candi 1, 2 , Gerry Melino 1, 3
Affiliation  

Regulatory noncoding RNAs (ncRNAs) are a class of RNAs transcribed by regions of the human genome that do not encode for proteins. The three main members of this class, named microRNA, long noncoding RNA, and circular RNA play a key role in the regulation of gene expression, eventually shaping critical cellular processes. Compelling experimental evidence shows that ncRNAs function either as tumor suppressors or oncogenes by participating in the regulation of one or several cancer hallmarks, including evading cell death, and their expression is frequently deregulated during cancer onset, progression, and dissemination. More recently, preclinical and clinical studies indicate that ncRNAs are potential biomarkers for monitoring cancer progression, relapse, and response to cancer therapy. Here, we will discuss the role of noncoding RNAs in regulating cancer cell death, focusing on those ncRNAs with a potential clinical relevance.



中文翻译:

非编码RNA在上皮癌中的作用

调节性非编码 RNA (ncRNA) 是一类由人类基因组中不编码蛋白质的区域转录的 RNA。该类的三个主要成员,即微小RNA、长链非编码RNA和环状RNA,在基因表达的调节中发挥着关键作用,最终塑造关键的细胞过程。令人信服的实验证据表明,ncRNA 通过参与一种或多种癌症标志的调节(包括逃避细胞死亡)来发挥抑癌基因或癌基因的作用,并且它们的表达在癌症发病、进展和扩散过程中经常失调。最近,临床前和临床研究表明 ncRNA 是监测癌症进展、复发和癌症治疗反应的潜在生物标志物。在这里,我们将讨论非编码 RNA 在调节癌细胞死亡中的作用,重点关注那些具有潜在临床相关性的 ncRNA。

更新日期:2020-04-24
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