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Potential therapeutic target for aging and age-related neurodegenerative diseases: the role of acid sphingomyelinase.
Experimental & Molecular Medicine ( IF 12.8 ) Pub Date : 2020-03-13 , DOI: 10.1038/s12276-020-0399-8
Min Hee Park 1, 2, 3 , Hee Kyung Jin 1, 4 , Jae-Sung Bae 1, 2, 3
Affiliation  

Aging, which is associated with age-related changes in physiological processes, is the most significant risk factor for the development and progression of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Accumulating evidence has indicated that sphingolipids are significant regulators that are associated with pathogenesis in aging and several age-related neurodegenerative diseases. In particular, abnormal levels of acid sphingomyelinase (ASM), one of the significant sphingolipid-metabolizing enzymes, have been found in the blood and some tissues under various neuropathological conditions. Moreover, recent studies have reported the importance of ASM as a critical mediator that contributes to pathologies in aging and age-related neurodegenerative diseases. In this review, we describe the pathophysiological processes that are regulated by ASM, focusing on the age-related neurodegenerative environment. Furthermore, we discuss novel insights into how new therapeutics targeting ASM may potentially lead to effective strategies to combat aging and age-related neurodegenerative diseases.

中文翻译:

衰老和与年龄有关的神经退行性疾病的潜在治疗靶点:酸性鞘磷脂酶的作用。

与年龄相关的生理过程变化相关的衰老是神经退行性疾病(包括阿尔茨海默氏病和帕金森氏病)发展和进展的最重要风险因素。越来越多的证据表明,鞘脂是与衰老和几种与年龄有关的神经退行性疾病的发病机理相关的重要调节剂。特别是,在各种神经病理学条件下的血液和某些组织中发现了异常水平的酸性鞘磷脂酶(ASM),这是一种重要的鞘脂代谢酶。此外,最近的研究报告了ASM作为关键介体的重要性,该介体有助于衰老和与年龄相关的神经退行性疾病的病理。在这篇评论中 我们描述了由ASM调节的病理生理过程,重点是与年龄有关的神经退行性环境。此外,我们讨论了针对ASM的新疗法如何潜在地导致抗击衰老和与年龄相关的神经退行性疾病的有效策略的新颖见解。
更新日期:2020-04-24
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