Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding,Nature Medicine

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Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding
Nature Medicine ( IF 82.9 ) Pub Date : 2020-03-13 , DOI: 10.1038/s41591-020-0817-4
Yi Xu ₁ , Xufang Li ₁ , Bing Zhu ₂ , Huiying Liang _{3,

4} , Chunxiao Fang ₁ , Yu Gong ₁ , Qiaozhi Guo ₅ , Xin Sun ₅ , Danyang Zhao ₅ , Jun Shen ₁ , Huayan Zhang _{1,

4,

6} , Hongsheng Liu ₇ , Huimin Xia _{3,

4,

8} , Jinling Tang _{3,

4} , Kang Zhang _{8,

9,

10} , Sitang Gong _{1,

4}

Affiliation

Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Department of Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Guangdong Provincial Children's Medical Research Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Department of Medical Administration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Division of Neonatology and Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.
Department of Radiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China.
Center for Biomedicine and Innovations, Faculty of Medicine, Macau University of Science and Technology, Macau, China.

We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. Chest X-rays lacked definite signs of pneumonia, a defining feature of the infection in adult cases. Notably, eight children persistently tested positive on rectal swabs even after nasopharyngeal testing was negative, raising the possibility of fecal–oral transmission.

中文翻译：

小儿 SARS-CoV-2 感染的特征和持续粪便病毒脱落的潜在证据

我们报告了对 SARS-CoV-2 RNA 的实时逆转录 PCR 测定证实的 10 例儿科 SARS-CoV-2 感染病例的流行病学和临床调查。这些病例的症状是非特异性的，没有儿童需要呼吸支持或重症监护。胸部 X 光片没有明确的肺炎迹象，这是成人病例感染的一个明确特征。值得注意的是，即使在鼻咽检测为阴性后，8 名儿童的直肠拭子检测仍持续呈阳性，这增加了粪口传播的可能性。

更新日期：2020-03-13

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