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COPD exacerbations: finally, a more than ACCEPTable risk score.
The Lancet Respiratory Medicine ( IF 76.2 ) Pub Date : 2020-03-13 , DOI: 10.1016/s2213-2600(20)30049-7
Surya P Bhatt 1
Affiliation  

Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with substantial respiratory morbidity, including major deterioration in functional status, accelerated decline of lung function, and mortality. Prevention of these exacerbations is imperative. To date, the strongest identified risk factor for future exacerbations seems to be history of previous exacerbations. However, this information does not provide any warning of a first exacerbation, which in many individuals can be a sentinel event in their disease course. Severe exacerbations are especially important as they are associated with rapid decline of lung function and 50% of patients die within 2 years after admission to hospital. Predicting these events might be the key to their prevention. Multiple attempts have been made to derive risk scores to predict COPD exacerbations, but these are limited by poor discrimination, inadequate calibration, or absence of external validation.

中文翻译:

COPD恶化:最后,超过ACCEPTable风险评分。

慢性阻塞性肺疾病(COPD)的急性加重与大量呼吸道疾病相关,包括功能状态的严重恶化,肺功能的加速下降和死亡率。预防这些恶化势在必行。迄今为止,确定的未来加重最强的危险因素似乎是先前加重的历史。但是,此信息不能提供任何关于首次加重的警告,在许多人中,这可能是他们病程中的前哨事件。严重加重尤为重要,因为它们与肺功能迅速下降有关,并且入院后2年内有50%的患者死亡。预测这些事件可能是预防这些事件的关键。
更新日期:2020-03-16
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