Urushiols are important active compounds found in the sap of the lacquer tree (Rhus verniciflua Stokes). Recently, various biological effects of urushiols, such as antioxidant, antimicrobial, and anticancer activities, have been reported. However, urushiols can also induce skin allergies. Nevertheless, the lacquer tree has traditionally been used in Korea as a folk medicine. In this study, we evaluated the absorption and metabolism of 3-pentadecylcatechol (PDC), a natural urushiol. PDC (48.0 mg/kg body wt.) in 1 mL propylene glycol was orally administered to rats (Sprague-Dawley, male, 6 weeks old). Blood plasma, urine, and feces were collected, separately. PDC was not detected in the extracts from rat blood plasma and urine. However, 89.4 ± 5.2% of the orally administered PDC was detected in the feces extracts, indicating that PDC was predominantly excreted and not absorbed.

漆酚是在漆树（Rus verniciflua）的汁液中发现的重要活性化合物。斯托克斯（Stokes）。近来，已经报道了漆酚的多种生物学作用，例如抗氧化剂，抗微生物剂和抗癌活性。但是，漆酚也可以引起皮肤过敏。然而，漆树在韩国传统上一直用作民间药。在这项研究中，我们评估了天然漆酚3-十八烷基邻苯二酚（PDC）的吸收和代谢。向大鼠（Sprague-Dawley，雄性，6周龄）口服给予1mL丙二醇中的PDC（48.0 mg / kg体重）。分别收集血浆，尿液和粪便。在大鼠血浆和尿液的提取物中未检测到PDC。但是，在粪便提取物中检测到口服PDC的89.4±5.2％，这表明PDC主要是排泄而未被吸收。